三种肿瘤标志物检验在肺癌诊断中的效果观察

Diagnostic efficacy of three tumor markers for lung cancer

目的 探讨糖类抗原(CA)153、CA125和癌胚抗原(CEA)三种肿瘤标志物检验在肺癌诊断中的效果。方法 选取2020年1月至2021年4月间上海市第二康复医院收治的100例肺癌患者为观察A组,收取100例肺部良性疾病患者为观察B组,另收取100例体检健康人员为对照组,检测三组受试者的CA153、CA125和CEA水平并进行比较。结果 观察A组患者CA153、CA125和CEA水平均高于观察B组和对照组,差异均有统计学意义(均P<0.05);观察B组和对照组各指标比较,差异无统计学意义(P>0.05)。联合检测真阳性率为32.7%(98/300),高于CA153、CA125和CEA单一检测,差异均有统计学意义(均P<0.05)。联合检测的敏感度、准确性和特异度均高于CA153、CA125和CEA单一检测,差异均有统计学意义(均P<0.05)。结论 CA153、CA125和CEA检验可提升肺癌临床诊断准确性,联合使用诊断效能更高,能够对患者的疾病分期、进展程度和预后效果等做出积极评估,值得推广。

Objective To analyze the clinical efficacy of Cancer antigen(CA)153, CA125 and carcinoembryonic antigen(CEA) tests for the clinical diagnosis of lung cancer. Methods One hundred patients with lung cancer were selected and included in observation group A, 100 patients with benign lung diseases were selected and included in observation group B, and 100 healthy individuals who had physical examination were included in a control group at Shanghai Second Rehabilitation Hospital between January 2020 and April 2021. CA153, CA125 and CEA levels were tested and compared among the three groups. Results The levels of CA153, CA125 and CEA were significantly higher in the observation group A than the rest two groups(all P<0.05). There was no significant difference between the observation group B and the control group(P>0.05). The true positive rate of the combination detection was significantly higher than that of each single detection of CA153, CA125, and CEA(P>0.05). Sensitivity, accuracy and specificity of the combination detection was significantly higher than that of each single CA153, CA125 and CEA test(all P<0.05). Conclusion CA153, CA125, and CEA tests can significantly improve the accuracy of clinical diagnosis for lung cancer patients, and especially the combined use has higher diagnostic efficiency. This method can effectively evaluate disease stage, degree of progression, and prognosis of patients. It is worthy of promotion.