原发性肺癌化疗患者发生静脉血栓栓塞的相关因素及干预对策研究

Risk factors and intervention strategies of venous thromboembolism in patients with primary lung cancer undergoing chemotherapy

目的 探讨原发性肺癌化疗患者发生静脉血栓栓塞(VTE)的相关因素及干预对策。方法 选取2018年5月至2020年5月间上海市宝山区仁和医院和同济大学附属上海市肺科医院收治的600例原发性肺癌化疗患者的临床资料,其中84例患者合并VTE,516例患者未并合。应用多因素Logistics回归模型分析影响原发性肺癌化疗患者发生VTE的相关因素,并分析干预对策。结果 单因素结果表明,VTE组与非VTE组比较,两组吸烟史、临床分期、合并心血管疾病和血清D-二聚体水平比较,差异有统计学意义(P<0.05)。多因素回归分析表明,临床分期、合并心血管疾病和血清D-二聚体水平为原发性肺癌化疗患者发生VTE的独立影响因素(P<0.05)。结论 临床分期、合并心血管疾病和血清D-二聚体水平为原发性肺癌化疗患者发生VTE的独立影响因素。

Objective To analyze the risk factors and interventions of venous thromboembolism(VTE) in primary lung cancer patients treated with chemotherapy. Methods The clinical data of 600 patients with primary lung cancer who received chemotherapy at Shanghai Renhe Hospital and Shanghai Pulmonary Hospital Affiliated to Tongji University from May 2018 to May 2020 were retrospectively analyzed. Among them, 84 patients had VET and 516 patients did not have VET. Multivariate logistics regression model was applied to analyze the related factors influencing the occurrence of VTE in patients with primary lung cancer undergoing chemotherapy, and the intervention strategies were analyzed. Results Univariate results showed that there were significant differences in smoking history, clinical stage, cardiovascular disease and serum D-dimer level between VTE group and non-VTE group(P<0.05). Multivariate logistic regression analysis showed that clinical stage, comorbidity of cardiovascular disease and serum D-dimer level were independent factors influencing VTE in patients with primary lung cancer undergoing chemotherapy. Conclusion Clinical stage, combined cardiovascular disease and serum D-dimer level were independent factors for VTE in patients with primary lung cancer undergoing chemotherapy.