长链非编码RNA在急性呼吸窘迫综合征中的研究进展

Research advance of long non-coding RNA in acute respiratory distress syndrome

急性呼吸窘迫综合征(ARDS)是临床上常见的危重病之一,起病急,预后较差,严重威胁人类的生命健康。迄今,ARDS的发生机制尚未完全阐明。长链非编码RNA是一种长度大于200个核苷酸的非编码RNA,可以在多个水平调控基因的转录与表达。研究表明,长链非编码RNA可以作为生物标志物预测ARDS的预后,并通过多种机制调控肺部炎症反应、凋亡、自噬等过程而参与ARDS的发生、发展。

Acute respiratory distress syndrome(ARDS)is one of the most common critical diseases in clinical practice with acute onset and poor prognosis,which threatens the life and health of human seriously.So far,the pathogenesis of ARDS has not been fully elucidated.Long non-coding RNA(LncRNA)is a kind of non-coding RNA with more than 200 nucleotides,and regulates the gene transcription and expression at multiple levels.It's reported that LncRNA could act as the biomarker to diagnose ARDS and predict the mortality of ARDS.Furthermore,LncRNA involves in the occurrence and development of ARDS by regulating pulmonary inflammation,apoptosis,and autophagy through various mechanisms.