摘要
Major depressive disorder(MDD) is the most common mental disorder. Over 95 million people in China suffer from MDD(Huang et al.,2019). Currently available antidepressants have delayed onset and a low cure rate(Malhi and Mann, 2018). Genetic and psychosocial factors, as well as their interactions, play an important role in the response to antidepressants for MDD patients(Uher, 2011;Gonda et al., 2019;Musci et al., 2019). Understanding the underlying associations and mechanisms may help to improve the first-episode cure rate in MDD patients.
基金
partly supported by the National Key R&D Program of China(2016YFC1306700)
the Key Projects of National Natural Science Foundation of China(81830040 and 82130042)
the Science and Technology Program of Guangdong,China(2018B030334001)
the Program of Excellent Talents in Medical Science of Jiangsu Province,China(JCRCA2016006)
the Social Science Foundation of Jiangsu Province,China(19GLB025)。
