铁代谢及其在心力衰竭治疗中的作用机制研究进展

Research progress of iron metabolism and its mechanism in the treatment of heart failure

心力衰竭(heart failure,HF)进展过程复杂,涉及多种信号通路的调控异常。其中,铁离子作为血红蛋白、肌红蛋白、氧化呼吸链及DNA合成酶等重要蛋白的辅因子,在心肌能量代谢过程中发挥着不可或缺的功能。近年来,大量研究表明心力衰竭与铁代谢紊乱相关,缺铁和铁过载均可导致多种心肌病的发病,最终进展为心力衰竭,铁代谢可能是心力衰竭诊断、预防和治疗的关键靶点。本文就机体铁代谢的基本过程及其在心力衰竭中的作用机制进行综述,以期为心力衰竭的治疗提供新的线索和依据。

The pathogenesis of heart failure is a complex progression and associated with abnormal regulation of many signaling pathways.As a cofactor of hemoglobin,myoglobin,oxidative respiratory chain,DNA synthase and other important proteins,iron plays an indispensable role in myocardial energy metabolism.Recently,a large number of studies have shown that heart failure is related to the disorder of iron metabolism.Both iron deficiency and iron overload can lead to the development of a variety of cardiomyopathy,and even progress to heart failure.Iron metabolism could be a key target for the diagnosis,prevention and treatment of heart failure.Here,we review the basic process of iron metabolism and its mechanism in heart failure,expecting to provide new clues and evidence for the treatment of heart failure.