气道上皮细胞铁死亡在哮喘中的作用:现状与展望

Ferroptosis of airway epithelial cells in asthma:current and future

铁死亡是近年提出的以细胞内铁依赖的脂质过氧化为主要特征的细胞死亡方式,其机制主要涉及脂质过氧化、铁累积和抗氧化系统失衡。近年来,有关铁死亡与哮喘的研究正逐渐深入。阐明铁死亡调控哮喘的分子机制,有助于拓宽对哮喘病理机制的理解。本文从脂质过氧化、铁累积和抗氧化系统失衡这3个角度,阐述气道上皮细胞铁死亡在哮喘发生发展过程中的作用,有望为哮喘治疗寻求新的靶点和策略。

Ferroptosis is a novel cell death mode proposed in recent years,which is characterized by intracellular iron-dependent lipid peroxidation.Its mechanisms include lipid peroxidation,iron accumulation and the imbalance of antioxidant system.The crosstalk between ferroptosis and asthma is gradually deepening.Elucidating the specific mechanism of ferroptosis in regulating asthma is helpful to broaden the understanding of the pathology of asthma.This paper expounds the role of ferroptosis in airway epithelial cells in the occurrence and development of asthma from three perspectives:lipid peroxidation,iron accumulation and the imbalance of antioxidant system,hoping to find new targets and strategies for asthma treatment.