破布木果中一对新的苯丙素对映异构体

A pair of new phenylpropanoid enantiomers from Cordia dichotoma fruits

综合应用正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC等多种分离方法对破布木(Cordia dichotoma Forst.f.)果醇提物的乙酸乙酯部位进行分离纯化,运用现代波谱技术(UV、IR、MS、NMR)进行结构鉴定,共分离得到10个化合物,分别鉴定为破布木酯(1)、(S)-2-羟基-3-(4′-羟基苯)丙酸(2)、香草酸(3)、对香豆素酸(4)、3-羟基-1-(4-羟基-3-甲氧基苯基)-1-丙酮(5)、苯甲酸(6)、对羟基苯丙酮(7)、对羟基苯乙酮(8)、5′-甲氧基楝叶吴萸素B(9)和香草醛(10)。其中化合物1为一对新的苯丙素对映异构体,化合物3、6、8、9为首次从该属植物中分离得到。

The ethyl acetate part of the alcoholic extract of Cordia dichotoma fruits was purified by a combination of normal-phase silica gel column chromatography,Sephadex LH-20 gel column chromatography and semipreparative HPLC,and the structure was identified by modern spectroscopic techniques(UV,IR,MS,NMR).A total of 10 compounds were isolated and identified as cordilide(1),(S)-2-hydroxy-3-(4′-hydroxyphenyl)propanoic acid(2),vanillic acid(3),p-coumaric acid(4),3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one(5),benzoic acid(6),p-hydroxypropiophenone(7),p-hydroxyacetophenone(8),5′-methoxyevofolin B(9)and vanillin(10).Among them,compound 1 is a pair of new phenylpropanoid enantiomers,and compounds 3,6,8 and 9 were isolated for the first time from the genus.