光成像在生物医药领域的研究前沿及热点分析

Research Frontier and Hotspots Analysis of Optical Imaging in Biomedical Research

以Web of Science数据库中1990—2020年光成像在生物医药领域6564篇相关学术论文和110篇高被引论文为研究对象,运用统计学和文献计量学软件CiteSpace对其文献分布特征和共被引作者、关键词共现等进行分析。结果表明:光声成像、纳米颗粒、光活检、光学相干层析成像、深度组织成像、细胞成像、探针、癌症诊治、药物传递、碳纳米管等是该领域的研究热点。近红外-Ⅱ光谱区内荧光成像、半导体聚合物纳米颗粒、光声成像以及光活检、肿瘤诊治成为当前生物医学光成像方面的前沿主题。深部组织光学成像、光治疗和光活检的有机半导体材料、光声成像造影剂以及二维钛纳米片在多模态成像引导的癌症治疗等方面显得尤为突出。

A total of 6564 academic papers and 110 highly cited papers on optical imaging in biomedical field from 1990 to 2020 in Web of Science database were selected as the research objects,and the distribution characteristics,co-authors and keywords co-occurrences were analyzed by using the statistics and bibliometric software CiteSpace.Results show that photoacoustic imaging,nanoparticles,optical biopsy,Oct,deep tissue imaging,cell imaging,probes,cancer theranostics,drug delivery,carbon nanotubes and other aspects are the research hotspots in this field.Near infrared-Ⅱspectral fluorescence imaging,semiconductor polymer nanoparticles,photoacoustic imaging,optical biopsy,tumor theranostics have become the frontier topics in biomedical optical imaging.The research in the following aspects are particularly prominent:deep tissue optical imaging,organic semiconductor materials for phototherapy and biopsy,photoacoustic imaging contrast agents and two-dimensional titanium nanosheets for multimodal imaging-guided cancer theranostics.