精氨酸代谢与常见妊娠相关疾病发生和发展

The relationship between arginine metabolism and pregnancy-related diseases

氨基酸作为蛋白质的基本组成单位,是维持妊娠和胎儿发育的必需物质。精氨酸对大多数哺乳动物的胚胎生长和生存而言是“条件必需的氨基酸”,是许多具有细胞信号转导功能和代谢功能的分子的前体。而妊娠被认为是一种精氨酸相对缺乏的状态,此时母体精氨酸的缺乏可能会对妊娠结局和胎儿带来不良影响。该文综述了精氨酸与先兆子痫、宫内生长受限和早产等常见妊娠相关疾病的最新研究进展,旨在为利用精氨酸干预并改善这些不良妊娠结局提供一定的理论基础。

As the basic building blocks of protein,amino acids are necessary for the maintenance of pregnancy and the normal development of fetus.Arginine is a″conditionally essential amino acid″for embryonic growth and survival in most mammals and is a precursor of many molecules involved in cellular signaling and metabolic functions.However,pregnancy is considered to be a state of relative arginine deficiency,and the lack of maternal arginine may have adverse effects on pregnancy outcome and fetal development.In this article,we summarized the recent studies regarding the effects and mechanisms of arginine on several common pregnancy-related diseases,i.e.,preeclampsia,intrauterine growth restriction and preterm birth,to provide theoretical basis for arginine intervention and improvement of these adverse pregnancy outcomes.