乌灵胶囊治疗失眠症疗效的Meta分析

Meta analysis of Wuling capsules in insomnia treatment

目的系统评价乌灵胶囊治疗失眠症的临床疗效。方法以"乌灵胶囊、失眠症、Wuling capsule、insomnia"等为检索关键词,检索时限为自建库起至2022年1月,应用计算机检索PubMed、EMbase、中国知网、中国生物医学文献数据库、万方及维普数据库中与乌灵胶囊治疗失眠症相关的随机对照试验(RCT)文献,并进一步根据设计的纳排标准筛选文献及收集相关资料(采用常规西药如苯二氮卓类或新型非苯二氮卓类药物治疗为对照组,单用乌灵胶囊或常规西药治疗基础上合用乌灵胶囊为研究组;结局指标为总有效率、匹兹堡睡眠质量指数量表总分或睡眠障碍评定量表总分)。采用Revman5.4软件对获取的文献数据进行Meta分析。结果最终共纳入符合标准的RCT文献17篇,共计1493例患者,其中研究组749例,对照组744例。Meta分析显示:研究组的总有效率明显高于对照组[相对危险度(RR)=1.270,95%CI:1.200~1.340],匹兹堡睡眠质量指数量表总分均明显低于对照组[加权均数差(WMD)=-2.070,95%CI:-2.610~-1.520],睡眠障碍评定量表总分明显低于对照组(WMD=-4.180,95%CI:-4.900~-3.450),差异均有统计学意义(P<0.05)。结论乌灵胶囊单用或联合西药治疗失眠症的疗效优于常规西药,可更显著地改善睡眠质量。

Objective To systematically evaluate the clinical efficacy of Wuling capsules in the treatment of insomnia.Methods The randomized controlled trial(RCT)literature related to the treatment of insomnia with Wuling capsules was searched by computer through PubMed,EMbase,China National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),Wanfang,and VIP databases.These RCT literature was searched by using"Wuling capsule and Insomnia"as keywords,and the search time frame was from the establishment of each database to January 2022.The literature was screened and relevant data were collected according to the designed nesting criteria(patients accepted conventional western medicines such as benzodiazepines or new non-benzodiazepines were used as control group,and patients accepted Wuling capsules alone or combined with conventional western medicines were used as study group;the outcome measures included total response rate,total scores of Pittsburgh Sleep Quality Index or Sleep Disorders Rating Scale),and Meta-analysis was performed on the extracted literature data using Revman 5.4 software.Results A total of 17 pieces of RCT literature met the criteria were finally included,with a total of 1493 patients,including 749 patients into the study group and 744 patients into the control group.The overall efficiency of the study group was significantly higher than that of the control group(relative risk[RR]=1.270,95%CI:1.200-1.340,P<0.05),and total scores of Pittsburgh Sleep Quality Index scale in study group were significantly lower than those in the control group(weighted mean difference[WMD]=-2.070,95%CI:-2.610--1.520,P<0.05),and the total scores of Sleep Disorder Rating Scale in study groups were significantly lower than those in the control group(WMD=-4.180,95%CI:-4.900--3.450,P<0.05).Conclusion The efficacy of Wuling capsules alone or combined with conventional western medicines in treating insomnia is better than that of conventional western medicines,and can obviously improve the quality of sleep of patients.