胆红素与精神分裂症的相关研究进展

Recent advance in correlation between bilirubin and schizophrenia

近期研究发现人体内高水平胆红素与精神分裂症存在一定的相关性:新生儿时期高水平胆红素可增加成人罹患精神分裂症的风险,合并高胆红素血症的成年精神分裂症患者精神症状更重。与其他类型精神疾病患者和正常人群相比,精神分裂症患者的胆红素水平普遍更高,并且这些较高水平的胆红素与精神分裂症的急性发作、阳性症状及不良预后相关。本文现综述胆红素与精神分裂症的关系及其潜在的病理生理机制,以期为精神分裂症的发病机制及辅助诊断研究提供新的方向。

Recently,accumulating evidence suggests that high bilirubin level is involved in the pathophysiology of schizophrenia.High bilirubin level during early childhood may increase the risk of being suffered from schizophrenia after adulthood,and schizophrenia patients with high bilirubin level have aggravated psychiatric symptoms.As compared with other psychiatric patients and general population,schizophrenia patients usually have relatively higher bilirubin level;high bilirubin level is associated with acute psychotic states,positive symptoms,and poor prognosis in patients with schizophrenia.This article reviews the relation between bilirubin and schizophrenia and its potential pathophysiological mechanism in order to provide a new direction for the study of schizophrenia pathogenesis and auxiliary diagnosis.