二氧化碳激光+光动力疗法治疗尖锐湿疣后短期复发的危险因素分析

Risk factors for short-term recurrence of condyloma acuminatum after the application of CO_(2) laser and photodynamic therapy

目的探讨二氧化碳激光+光动力疗法治疗尖锐湿疣(CA)后短期复发的危险因素。方法纳入成都市龙泉驿区第一人民医院2018年1月至2019年1月收治的CA病人102例,均采用二氧化碳激光+光动力疗法。根据病人治疗后1个月的复发情况,将其分成复发组、未复发组。收集所有病人的临床资料,包括性别、年龄、病程、婚姻状况、疣数目、疣大小、文化程度、吸烟史、饮酒史、熬夜、性伴侣数量、安全套使用、同性恋。经logistic回归模型分析CA病人经二氧化碳激光+光动力疗法治疗后短期复发的危险因素。结果在102例病人中,有23(22.55%)例复发,79(77.45%)例未复发。复发组疣数目≥10个、疣大小≥0.5 cm、性伴侣数量≥3个、从不使用安全套的占比显著高于未复发组(P<0.05)。logistic回归性分析提示,疣数目≥10个、疣大小≥0.5cm、性伴侣数量≥3个、从不使用安全套是CA病人二氧化碳激光+光动力疗法短期复发的危险因素(P<0.05)。结论CA病人经二氧化碳激光+光动力疗法治疗后,短期内复发高危因素包括疣数目、疣大小、性伴侣数量、安全套使用情况,临床需引起重视。

Objective To investigate the risk factors of short-term recurrence of condyloma acuminatum(CA)after the application of CO_(2) laser and photodynamic therapy.Methods A total of 102 CA patients admitted to Longquanyi District First People's Hospital of Chengdu City from January 2018 to January 2019 were included and treated with CO_(2) laser and photodynamic therapy.According to the recurrence of patients within 1 months after treatment,they were assigned into recurrence group and non-recurrence group.Clinical data of all patients were collected,including gender,age,course of disease,marital status,number of warts,size of warts,educational background,smoking and drinking history,staying up late,number of sexual partners,condom use,and homosexuality.Logistic regression model was used to analyze the risk factors of short-term recurrence in CA patients after the application of CO_(2) laser and photodynamic therapy.Results Of the 102 patients,CA recurred in 23(22.55%)patients and did not recur in 79(77.45%)patients.The number of warts≥10,the size of warts≥0.5cm,the number of sexual partners≥3 and the proportion of patients never using condom in the recurrent group were significantly higher than those in the non-recurrence group(P<0.05).Logistic regression analysis results showed that the number of warts≥10,the size of warts≥0.5 cm,the number of sexual partners≥3 and never using condom were the risk factors of short-term recurrence(P<0.05).Conclusion After treatment with CO_(2) laser and photodynamic therapy,the high-risk factors of recurrence in a short period of time include the number of warts,the size of warts,the number of sexual partners,and the use of condoms,which is worthy of attention in clinical practice.