摘要
Bone cancer is a critical health problem on a global scale,and the associated huge clinical and economic burdens are still rising.Although many clinical approaches are currently used for bone cancer treatment,these methods usually affect the normal body functions and thus present significant limitations.Meanwhile,advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone regeneration.This paper presents a comprehensive review of bone cancer and its current treatment methods,particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials,drug-loaded scaffolds,and scaffolds for photothermal/magnetothermal therapy.Finally,the main research challenges and future perspectives are elaborated.
基金
the Engineering and Physical Sciences Research Council(EPSRC)UK through the Global Challenges Research Fund(No.EP/R015139/1)
Rosetrees&Stoneygate Trust Enterprise Fellowship(Ref:A2750/M874)from Rosetrees Trust UK and Stoneygate Trust UK.