联合用药对嗜水气单胞菌耐药性影响研究进展

Advances in Research on the Effects of Joint Medication on the Drug Resistance of Aeromonas hydrophila

嗜水气单胞菌(Aeromonas hydrophila)是威胁水产养殖业安全最严重的病原微生物之一,同时还存在人畜共患的典型特征。随着抗生素、抗菌药物的主动使用和被动暴露(医院生活废水、畜禽养殖污水排放至养殖水体环境),嗜水气单胞菌多重耐药问题日益突出,给水产养殖和人体健康均带来潜在风险。而合理联合用药不仅可减缓和阻控细菌耐药性产生,还能减少药物残留。本文首先分析联合用药遵循的原则及应关注的方向,阐述耐药产生的原因及联合用药影响耐药性的作用机制,综述研究联合用药阻控嗜水气单胞菌耐药性的动态进展,最后提出如何推进的思考和展望,旨在为水产养殖业通过联合用药手段控制嗜水气单胞菌耐药性提供防控策略和解决手段。

Aeromonas hydrophila is one of the most serious pathogenic microorganisms threatening the aquaculture industry,and it also has characteristic of zoonotic diseases.Due to the using of antibiotics or antibacterial drugs and exposure to hospitals wastewater,livestock and poultry farming wastewater,the problem of multi-drug resistance of A.hydrophila has become increasingly prominent,which contributes potential risks to the aquiculture safety and human being health.The rational joint medicationcan not only slow down and prevent the emergence of bacterial resistance,but also reduce drug residues.This paper first analyzes the principles followed by the joint medication and the direction to be paid attention to,expounds the causes of drug resistance and the mechanism of the effect of the joint medication on drug resistance,and synthesizes the dynamics progress of the joint medication to block drug resistance in A.hydrophila.Finally,the thoughts and prospects of how to proceed are proposed,aiming to provide prevention and control strategies and solutions for the aquaculture industry to control the drug resistance of A.hydrophila through joint medication.