miRNA序列及其靶基因结合位点的单核苷酸多态性对畜禽生产性状调控的研究进展

Research Progress on the Regulation of Single Nucleic Polymorphism in miRNA Sequence and Its Target Gene Binding Site on Livestock Production Traits

miRNA是一类小的非编码RNA,通过与靶基因mRNA 3’UTR区互补配对引起靶基因降解或翻译抑制,从而发挥调节作用。靶基因3’UTR区域内miRNA结合位点的SNP可能会破坏或产生新的结合位点,使基因表达水平发生变化。本文综述了与miRNA相关SNP对畜禽生产性状影响的研究进展,为进一步研究将miRNA相关多态性位点作为畜禽品种选育的潜在分子标记、培育具有优良生产性状的畜禽品种提供理论基础。

miRNA is a kind of small non coding RNA, which play a regulatory role by complementary pairing with the 3’UTR region of the target gene mRNA, causing degradation or translation inhibition of the target gene. SNPs of miRNA binding sites in the 3’UTR region of the target gene may destroy or produce new binding sites, resulting in changes in gene expression.This paper reviews the research progress on the effects of miRNA related SNPs on livestock and poultry production traits, so as to provide a theoretical basis for further research on using miRNA related polymorphic loci as potential molecular markers for livestock and poultry breeding and cultivating livestock and poultry varieties with excellent production traits.