超重与肥胖对心血管疾病归因负担研究

Burden of cardiovascular diseases attributable to overweight and obesity

目的 分析心血管疾病归因于超重、肥胖人群的归因负担。方法 从中国高血压调查中选取35岁及以上研究对象的基线资料和随访的心血管结局事件。采用人群归因百分比(PAF)评估超重、肥胖造成的全国及各省份心血管疾病负担。结果 在平均4.56年的随访中,有349例冠心病事件和672例脑卒中事件发生。在全国层面,超重和肥胖对心血管疾病的PAF分别为6.20%(95%CI=6.16~6.24)和7.08%(95%CI=6.99~7.17),对冠心病的PAF分别为6.84%(95%CI=6.80~6.89)和10.78%(95%CI=10.65~10.90),脑卒中PAF分别为8.72%(95%CI=8.66~8.78)和6.96%(95%CI=6.87~7.04)。对于各省而言,北方地区PAF较高,南方地区PAF较低。结论 中国心血管疾病很大比例可归因于肥胖,且不同地区存在显著差异。

Objective To analyze the results of the attribution burden of cardiovascular disease(CVD) to overweight and obesity. Methods Baseline data and follow-up cardiovascular outcomes of subjects aged 35 years and older were selected from the Chinese Hypertension Survey.Population attributable fraction(PAF) was used to assess the burden of CVD caused by overweight and obesity in China and 31 provinces. Results During a mean follow-up of 4.56 years, 349 coronary heart diseases and 672 strokes occurred. At national level, the PAF of CVD was 6.20% [95%(CI)=6.16-6.24] for overweight, 7.08%(95%CI=6.99-7.17) for obesity;for coronary heart disease, 6.84%(95%CI=6.80-6.89) and 10.78%(95%CI=10.65-10.90);for stroke, 8.72%(95%CI=8.66-8.78) and 6.96%(95%CI=6.87-7.04). At province level, the PAF was higher in north provinces lower in south provinces. Conclusion There are strikingly different across geographic regions, with a large proportion of CVD in China are attributable to obesity.