摘要
姜黄素属于二酮类化合物,是从姜黄属类植物的根茎中提取出的一种橙黄色结晶粉末,具有广泛的药理活性。动脉粥样硬化会引起冠心病、脑卒中和其他器官发生继发性病变,严重威胁人们的身体健康。研究发现姜黄素可以通过抑制炎症反应、减少氧化应激、抗凝、调脂、降血压、促进糖代谢、调控平滑肌细胞增殖和迁移、减少病理性新生血管数量、保护血管内皮细胞等途径影响动脉粥样硬化进程。查阅近些年相关文献对姜黄素抗动脉粥样硬化的作用机制及研究进展作一综述。
Curcumin is a diketone compound.It is an orange-yellow crystalline powder extracted from the rhizomes of plants of Curcuma.It has a wide range of pharmacological activities.Atherosclerosis can cause coronary heart disease,cerebral infarction and secondary diseases of other organs,which seriously threaten people’s health.Studies have found that curcumin can delay atherosclerosis by inhibiting inflammation,reducing oxidative stress,preventing coagulation,lowering lipids,lowering blood pressure,promoting glucose metabolism,regulating smooth muscle cell proliferation and migration,decreasing the number of pathological new blood vessels and protecting vascular endothelial cells.This study retrieved relevant literature in recent years to review the mechanism and research progress of curcumin against atherosclerosis.
作者
王梦楠
秦合伟
郭宁
宋雪梅
牛雨晴
孙孟艳
WANG Mengnan;QIN Hewei;GUO Ning;SONG Xuemei;NIU Yuqing;SUN Mengyan(Henan University of Chinese Medicine, Zhengzhou 450046, China;Henan Province Hospital of TCM, Zhengzhou 450002, China)
出处
《中医药学报》
CAS
2022年第7期116-120,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金项目(81704030)
河南省科技攻关计划项目(212102310359)
河南省中医药科学研究专项重点课题(20-21ZY1023)
河南省中医药拔尖人才培养项目资助(豫卫中医函〔2021〕15号)
中原英才计划—中原青年拔尖人才资助(豫组通〔2021〕44号)。
关键词
动脉粥样硬化
姜黄素
炎症
氧化应激
Atherosclerosis
Curcumin
Inflammation
Oxidative stress
