男性9号染色体倒位对辅助生殖结局影响的研究

Study about the influence of male chromosome 9 inversion on the outcome of assisted reproduction

目的 探究男性9号染色体倒位是否会对辅助生殖结局产生影响。方法 以2010年至2020年于我科就诊并行体外受精-胚胎移植或卵母细胞内单精子注射治疗的夫妇为研究对象,以其中男方存在9号染色体倒位者为实验组,以染色体均正常的夫妇为对照组。收集整理两组的精液检查结果、临床资料,回顾性分析其临床结局。结果 本次研究中实验组和对照组的精液体积、浓度、存活精子数、前向运动精子数和形态正常精子率差异没有统计学意义;IVF实验组患者弱精子症的发生率显著高于对照组,ICSI实验组患者畸形精子症的发生率显著高于对照组;实验组和对照组卵子的正常受精率、异常受精率、卵裂率、可用胚胎形成率、胚胎种植率、临床妊娠率、流产率和活产率差异没有统计学意义。结论 存在9号染色体倒位患者发生弱精子症或畸形精子症的概率高于对照组,但男性9号染色体倒位基本不会对辅助生殖结局产生影响。

Objective To explore whether the male chromosome 9 inversion affects the assisted reproductive outcome.Methods The couples who visited our department from 2010 to 2020 and received in vitro fertilization-embryo transplantation or intracytoplasmic sperm injection treatment were taken as the research objects. The couples whose male partner had chromosome 9 inversion were taken as the experimental group, the couples whose chromosomes were all normal were taken as the control group. The semen examination results, clinical data and the clinical outcomes of the two groups were collected and analyzed. Results In this study, there were no significant difference in semen volume, concentration, viable sperm count, forward moving sperm count and morphologically normal sperm rate between experimental group and control group. The incidence of asthenospermia in IVF experimental group was significantly higher than that in the control group, while the incidence of teratospermia in ICSI experimental group was significantly higher than that in the control group. There was no statistically significant difference in normal fertilization rate, abnormal fertilization rate, cleavage rate, available embryo formation rate,embryo implantation rate, clinical pregnancy rate, abortion rate and live birth rate between experimental group and control group. Conclusion The incidence of asthenospermia or teratospermia in patients with chromosome 9 inversion is higher than that in the control group, but the male chromosome 9 inversion didn’t affect the assisted reproductive outcome.