阿司匹林在子痫前期预防中的应用现状及进展

Application status and progress of aspirin in the prevention of preeclampsia

子痫前期是母儿患病率和死亡率的主要原因之一,该病病情进展迅速,可允许期待治疗的时间窗短,部分患者即使及时终止妊娠,仍有并发子痫、HELLP综合征、多器官功能衰竭等风险。因此,如何在妊娠早期采取积极有效的措施预防子痫前期的发生,至关重要。阿司匹林具有促血管生成、抗血小板聚集以及抗炎的作用,在子痫前期发病的多个靶点中起作用,可预防或延缓子痫前期的发生。目前被广泛地用于有子痫前期发病风险的高危孕妇,但其在妊娠期间的最佳应用,仍未有统一的标准。本文对阿司匹林在子痫前期预防中的应用现状及进展进行综述。

Preeclampsia is one of the main causes of maternal as well as neonatal morbidity and mortality. The disease progresses rapidly and allows a short time window for expectant treatment. Some patients still have the risk of eclampsia,HELLP syndrome and multiple organ failure even if the pregnancy is terminated in time. Therefore, how to take active and effective measures to prevent the occurrence of preeclampsia in early pregnancy is very important. Aspirin has the effects of promoting angiogenesis, antiplatelet and anti-inflammatory. It can act on multiple targets of preeclampsia and prevent or delay the occurrence of preeclampsia. At present, it is widely used in high-risk pregnant women with preeclampsia risk. However,there is no unified standard for its optimal application during pregnancy. This article reviews the application status and progress of aspirin in the prevention of preeclampsia.