依卡倍特钠联合奥美拉唑四联疗法治疗Hp阳性慢性萎缩性胃炎患者的疗效及血清炎性因子水平分析

Efficacy and serum inflammatory factor levels of icabete sodium combined with omeprazole quadruple therapy in patients with Hp-positive chronic atrophic gastritis

目的:探究依卡倍特钠联合奥美拉唑四联疗法治疗幽门螺旋菌(Helicobacter pylori,Hp)阳性慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)患者的疗效。方法:选取2020年7月至2021年7月我院Hp阳性CAG胃炎患者122例,根据治疗方法不同分为对照组和观察组,各61例,对照组采用奥美拉唑四联疗法,观察组加用依卡倍特钠治疗。观察两组疗效、Hp根除率、病损面积、血清白介素-6(Serum interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、超敏C反应蛋白(High-sensitivity C-reactive protein,hs-CRP)、内皮素(Endothelin,ET)、胃蛋白酶I(Pepsin I,PGI)、胃蛋白酶II(Pepsin II,PGII)、促胃液素(Gastrin,GAS)水平及不良反应率。结果:观察组总有效率、Hp根除率均高于对照组(P<0.05);治疗后与对照组相比,观察组病损面积明显缩小(P<0.05);治疗后观察组IL-6、TNF-α、hs-CRP、ET水平低于对照组,PGI、PGII、GAS水平高于对照组(P<0.05);观察组不良反应率与对照组无明显差异。结论:在奥美拉唑四联疗法基础上,加用依卡倍特钠治疗Hp阳性CAG胃炎的效果显著,能有效改善患者炎症反应,调节胃肠道运动功能,从而减轻临床病症。

Objective:To investigate the efficacy of icabete sodium combined with omeprazole quadruple therapy in the treatment of patients with Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods:A total of 122 patients with Hp-positive CAG gastritis in our hospital from July 2020 to July 2021 were selected and divided into control group and observation group according to different treatment methods,with 61 cases in each group.The control group received omeprazole quadruple therapy,and the observation group was additionally treated with icabetite sodium on the basis of control group.The curative effect,Hp eradication rate,lesion area,serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),endothelin(ET),pepsin I(PGI),pepsin II(PGII),gastrin(GAS)levels and adverse reaction rates were observed in the two groups.Results:The total effective rate and Hp eradication rate in the observation group were higher than those in the control group(P<0.05).After treatment,compared with the control group,the lesion area of the observation group was significantly reduced(P<0.05).The levels of TNF-α,hs-CRP and ET were lower than those in the control group,while the levels of PGI,PGII and GAS were higher than those in the control group(P<0.05).There was no significant difference in the adverse reaction rate between the observation group and the control group.Conclusion:On the basis of omeprazole quadruple therapy,the addition of icabet sodium in the treatment of Hp-positive CAG gastritis has a significant effect,which can effectively improve the inflammatory response of patients,regulate gastrointestinal motor function,and relieve clinical symptoms.