CO_(2)冷冻治疗高危型HPV感染合并宫颈柱状上皮异位效果及对HPV转阴率的影响

Effect of CO_(2) cryotherapy on high-risk HPV infection complicated with ectopic cervical columnar epithelium and its effect on HPV negative rate

目的探讨CO_(2)冷冻治疗高危型人乳头瘤病毒(HPV)感染合并宫颈柱状上皮异位效果及对HPV转阴率的影响。方法选取80例高危型HPV感染合并宫颈柱状上皮异位患者,应用随机数字表法分为治疗组与对照组,每组40例。对照组患者应用重组人干扰素α-2b凝胶治疗,治疗组在对照组基础上应用CO_(2)冷冻治疗。对比两组患者HPV转阴率、HPV病毒载量及临床疗效。结果治疗组患者6个月后HPV转阴率明显高于对照组,HPV病毒载量明显低于对照组,差异具有统计学意义(P<0.05)。治疗组总有效率为92.50%,明显高于对照组的70.00%,差异具有统计学意义(P<0.05)。结论高危型HPV感染合并宫颈柱状上皮异位患者在常规治疗基础上联合CO_(2)冷冻治疗能够提升HPV转阴率,减少HPV病毒载量,疗效确切,值得临床推广与应用。

Objective To investigate the effect of CO_(2) cryotherapy on high-risk human papillomavirus(HPV)infection complicated with ectopic cervical columnar epithelium and its effect on the negative rate of HPV.Methods 80 patients with high-risk HPV infection complicated with ectopic cervical columnar epithelium were randomly divided into treatment group and control group with 40 cases in each group.Patients in the control group were treated with recombinant human interferon α-2b gel treatment,the treatment group was treated with CO_(2) cryotherapy on the basis of the control group.The HPV negative rate,HPV viral load and clinical efficacy were compared between the two groups.Results After 6 months,the negative rate of HPV in the treatment group was significantly higher than that in the control group,and the HPV viral load was significantly lower than that in the control group(P<0.05).The total effective rate of the treatment group was 92.50%,which was significantly higher than that of the control group(70.00%).The diflFerence was statistically significant(P<0.05).Conclusion High-risk HPV infection complicated with ectopic cervical columnar epithelium combined with CO_(2) cryotherapy on the basis of routine treatment can improve the negative rate of HPV reduce HPV viral load,and have definite curative effect,which is worthy of clinical promotion and application.