氧化三甲胺在冠心病中的研究进展

Research progress of TMAO in coronary heart disease

冠心病目前仍是世界上最常见的死亡原因,所以针对冠心病的预防及治疗至关重要。近年来,研究表明,氧化三甲胺(TMAO)可能是冠心病发生发展的潜在危险因素,大量实验发现,TMAO与心血管事件的发生存在着明显的正相关,它可通过加快泡沫细胞的形成、干扰胆固醇和胆汁酸的代谢、参与血管炎症和内皮功能损害、促使血小板活化及血栓形成等机制来加快动脉粥样硬化的发生。因此,探讨TMAO与冠心病之间的关系可能为冠心病的预防及治疗带来新的见解。本文主要综述了TMAO与冠心病之间的联系及其在冠心病预防治疗中的研究进展。

Coronary heart disease is still the most common cause of death in the world,so the prevention and treatment of coronary heart disease is very important.In recent years,some studies have found that there is a close relationship between TMAO and the occurrence,development and treatment of coronary heart disease.This article mainly reviews the relationship between TMAO and coronary heart disease and its research progress in the prevention and treatment of coronary heart disease.