盐酸屈他维林联合氯诺昔康注射治疗尿石症肾绞痛的效果

Effectiveness of drotaverine hydrochloride combined with lornoxicam injection in treating renal colic caused by urolithiasis

目的明确盐酸屈他维林注射液联合氯诺昔康注射液在缓解尿石症肾绞痛中的有效性和安全性。方法选取2020年8月-2020年11月在山东省立第三医院就诊的尿石症肾绞痛患者120例,将患者随机分为3组,每组40例患者,试验组给予静推氯诺昔康注射液8 mg+静滴盐酸屈他维林注射液80 mg,对照1组给予静推氯诺昔康注射液8 mg+静滴间苯三酚注射液120 mg,对照2组仅给予静推氯诺昔康注射液8 mg,观察12 h,观察期内记录患者治疗2、4、6、8、12 h的疼痛视觉模拟评分,对评分进行数据整理,记录观察期内给予二次镇痛药物干预的人数以及药物不良反应。结果试验组在治疗后8、12 h的疼痛总缓解率和疼痛缓解程度要明显优于两个对照组,差异有统计学意义(P<0.05);试验组在观察期内二次镇痛的比例要明显少于两个对照组,差异有统计学意义(P<0.01),试验组在观察期内不良药物反应的发生率3组间差异无统计学意义(P>0.05)。结论屈他维林作为一种生物半衰期较长的平滑肌解痉药,联合非甾体类抗炎镇痛药,对急性肾绞痛患者的疼痛症状有较长的镇痛维持时间以及较好的疼痛缓解效果,同时能减少再次镇痛干预的几率,没有显著增加药物不良反应,值得临床推广应用。

Objective To evaluate the efficacy and safety of drotaverine hydrochloride injection plus lornoxicam injection in relieving renal colic caused by urolithiasis.Methods A total of 120 patients with renal colic caused by urolithiasis were randomly divided into 3 groups,with 40 in each group.The experimental group was given lornoxicam injection 8 mg+drotaverine hydrochloride injection 80 mg,control group 1 was given lornoxicam injection 8 mg+phloroglucinol injection 120 mg,and control group 2 was given lornoxicam injection 8 mg only.All groups were observed for 12 hours,and the patients Visual Analog Scale scores were recorded at 2,4,6,8 and 12 hours of treatment.The number of patients who required a second analgesic intervention and the adverse drug reactions were recorded.Results The total pain relief rate and pain relief degree of the experimental group at 8 and 12 hours after treatment were significantly higher than those of the two control groups(P<0.05).Significantly fewer patients required analgesics for the second time in the experimental group than in the two control groups(P<0.01).There was no significant difference in the incidences of adverse drug reactions between the experimental group and two control groups(P>0.05).Conclusion Drotaverine combined with non-steroidal anti-inflammatory analgesics has a longer analgesic maintenance time and a better pain relief effect on patients with renal colic and reduces the probability of repeated analgesic intervention,without significantly increasing adverse drug reactions.