摘要
N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5.
基金
supported by the National Key Research Program(No.2018YFE0195100)
the National Natural Science Foundation of China (No.82020108030,No.U21A20416 and No.82103997)
Science and Technology Innovation Talents of Henan Provincial Education Department (No.19IRTSTHN001,China)
Basic and Frontier Technology Research Project of Henan Province (No.212102310313,China)
Basic Research of the Key Project of the High Education from the Education Department of Henan Province (No.22ZX008,China)。
