育龄妇女血清硒元素对血脂的短期影响

The short-term effects of serum selenium on lipids in women of childbearing age

血清硒元素与血脂的关系尚存在争议,两者之间可能存在非线性关联,目前仍缺乏相关可靠证据.本文采用定组研究设计,募集35名育龄妇女进行5次调查,每次均采集并分析血清硒元素和血脂浓度,以探讨育龄妇女体内血清硒元素对血脂的短期影响.分析表明,除甘油三酯外,血清硒元素与总胆固醇(P=0.005)、高密度脂蛋白胆固醇(P<0.001)、低密度脂蛋白胆固醇(P<0.001)、非高密度脂蛋白胆固醇(P=0.01)和脂蛋白(a)(P=0.03)之间关联的非线性检验均具有统计学意义.仅硒元素浓度在80—130 ng·mL^(−1)时,硒与总胆固醇呈线性关系;仅硒元素浓度在80—140 ng·mL^(−1)时,硒与高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇呈线性关系.整体而言,血清硒元素与血脂浓度之间是非线性关联,在一定浓度范围内,硒浓度升高短期内可能会使血脂浓度升高.

The associations between serum selenium and blood lipids are still controversial,and there may exist nonlinear relationships between them.However,there is a lack of relevant reliable evidence until now.A panel study design was adopted in this study.A total of 35 women of childbearing age were recruited and visited for 5 times.The concentrations of serum selenium and serum lipids were measured during each visit to explore the short-term effects of serum selenium on lipids.Statistically significant nonlinear relationships were found between serum selenium and total cholesterol(P=0.005),high-density lipoprotein cholesterol(P<0.001),low-density lipoprotein cholesterol(P<0.001),non-high-density lipoprotein cholesterol(P=0.01)and lipoprotein(a)(P=0.03),respectively,while not for triglyceride.Only when serum selenium was within 80—130 ng·mL^(−1),it was linearly associated with total cholesterol.Only when serum selenium was within 80—140 ng·mL^(−1),it was linearly associated with high-density lipoprotein cholesterol,low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol.In conclusion,there were non-linear relationships between serum selenium and serum lipids in women of childbearing age.Within a certain range of serum selenium concentration,the blood lipid concentrations increase with serum selenium increasing in a short period.