腹腔镜手术联合化疗对宫颈癌患者生存状态和HPV载量的影响

Effect of Laparoscopic Surgery Combined with Chemotherapy on Survival Status and HPV Load in Patients with Cervical Cancer

目的:探讨腹腔镜手术联合化疗对宫颈癌患者生存状态和人乳头瘤病毒(HPV)载量的影响。方法:选取2012年2月-2018年2月在莆田学院附属医院确诊为宫颈癌并进行诊治患者134例,按随机抽样法分为观察组和对照组,各67例,对照组实施腹腔镜手术治疗,观察组进行腹腔镜手术联合化疗。对比两组临床资料、3年无进展生存率及总生存率、HPV病毒载量及生存质量。结果:观察组临床资料优于对照组(P<0.05);观察组3年无进展生存率(64.18%)较对照组(31.34%)高,且观察组3年总生存率(95.52%)高于对照组(83.58%)(P<0.05)。治疗前,两组HPV病毒载量比较,差异无统计学意义(P>0.05),术后2个月,两组HPV病毒载量均低于治疗前,观察组HPV病毒载量明显低于对照组,差异有统计学意义(P<0.05)。术后2个月,对照组生存状态评分低于观察组(P<0.05)。结论:腹腔镜手术联合化疗应用于宫颈癌患者,可缩短患者住院、手术时间,加快术后胃肠道功能恢复,提高3年总生存率,降低HPV载量水平,提高患者的生存质量。

Objective:To investigate the effects of laparoscopic surgery combined with chemotherapy on survival status and human papillomavirus(HPV)load in patients with cervical cancer.Method:A total of 134 patients diagnosed with cervical cancer in Affiliated Hospital of Putian University from February 2012 to February 2018 were selected and divided into observation group and control group by random sampling method,67 cases in each group.The control group was treated with laparoscopic surgery,and the observation group was treated with laparoscopic surgery combined with chemotherapy.Clinical data,3-year progression free survival rate and overall survival rate,HPV viral load and quality of life were compared between two groups.Result:The clinical data of the observation group were better than those of the control group(P<0.05).The 3-year progression-free survival rate(64.18%)in the observation group was higher than that in the control group(31.34%),and the 3-year overall survival rate(95.52%)in the observation group was higher than that in the control group(83.58%)(P<0.05).Before treatment,there was no significant difference in HPV viral load between the two groups(P>0.05);two months after surgery,HPV viral load levels in both groups were lower than those before treatment,HPV viral load level in observation group was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Two months after surgery,the survival status scores of the control group were lower than those of the observation group(P<0.05).Conclusion:Laparoscopic surgery combined with chemotherapy in patients with cervical cancer can shorten the hospitalization,operation time,accelerate postoperative recovery of gastrointestinal function,improve the 3-year overall survival rate,decrease the HPV load level,and improve the quality of life.