乙酰半胱氨酸雾化吸入辅助糖皮质激素治疗儿童支气管肺炎的效果

Effect of Acetylcysteine Atomization Inhalation Auxiliary Glucocorticoid in the Treatment of Bronchopneumonia in Children

目的:观察乙酰半胱氨酸雾化吸入辅助糖皮质激素治疗儿童支气管肺炎的效果。方法:选取2021年1-6月徐州市妇幼保健院儿科住院支气管肺炎患者90例为治疗对象。随机将其分为观察组和对照组,各45例。两组均进行常规治疗,对照组给予布地奈德治疗,观察组增加雾化吸入乙酰半胱氨酸治疗。比较两组临床疗效、症状消退时间、治疗前后炎症因子及安全性。结果:观察组总有效率为91.11%(41/45),高于对照组的73.33%(33/45)(P<0.05)。观察组喘息、咳嗽、气促消退时间及住院时间均优于对照组(P<0.05)。治疗后,观察组降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于对照组(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:乙酰半胱氨酸雾化吸入辅助糖皮质激素治疗儿童支气管肺炎的效果显著,能够促进患儿症状的消退,降低患儿炎症因子水平,治疗安全性较好,可临床推荐。

Objective:To observe effect of Acetylcysteine atomization inhalation auxiliary glucocorticoid in the treatment of bronchopneumonia in children.Method:A total of 90 pediatric inpatients with bronchopneumonia in Xuzhou Maternal and Child Health Hospital from January to June 2021 were selected as the treatment objects.They were randomly divided into observation group and control group,with 45 cases in each group.Both groups received routine treatment,the control group was treated with Budesonide,and the observation group was treated with atomization inhalation of Acetylcysteine.The clinical efficacy,symptom regression time,inflammatory factors before and after treatment and safety were compared between the two groups.Result:The total effective rate in the observation group was 91.11%(41/45),which was higher than 73.33%(33/45)in the control group(P<0.05).The regression time of wheezing,cough,shortness of breath and hospital stay in the observation group were better than those in the control group(P<0.05).After treatment,procalcitonin(PCT)and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)levels in the observation group were lower than those in the control group(P<0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of Acetylcysteine atomization inhalation auxiliary glucocorticoid in the treatment of bronchopneumonia in children is significant.It can promote the regression of symptoms and reduce the level of inflammatory factors in children.The treatment is safe and can be recommended clinically.