硝苯地平联合拉贝洛尔治疗妊娠期高血压疗效及对血清脂联素水平和血液黏度的影响

Effect of nifedipine combined with labetalol for treating women w ith hypertension during pregnancy,and its influence on their serum adiponectin level and blood viscosity

目的:探究硝苯地平联合拉贝洛尔治疗妊娠期高血压疗效及对患者血清脂联素水平及血液黏度的影响.方法:选取本院2019年10月-2021年5月收治的妊娠期高血压患者60例随机分为对照组(30例)和观察组(30例),均给予拉贝洛尔治疗,观察组联合硝苯地平治疗,比较血液黏度、血尿素氮、24h尿蛋白定量,血清脂联素、超敏C反应蛋白(hs-CRP)、亮氨酸氨基转肽酶(LAP)水平,临床疗效以及不良反应.结果:与治疗前比较,两组治疗后血液黏度、血清尿素氮、hs-CRP、24h尿蛋白定量水平、舒张压、收缩压水平均明显降低且观察组低于对照组,血清脂联素、LAP水平均升高且观察组高于对照组(均P<0.05);临床疗效观察组(90.0%)高于对照组(63.3%)(P<0.05);治疗期间食欲下降、下肢水肿、头晕乏力等症状总发生率观察组(30.0%)与对照组(13.3%)无差异(P>0.05).结论:硝苯地平联合拉贝洛尔治疗妊娠期高血压可有效调节患者血液黏度,降低炎症反应,升高血清脂联素及LAP水平,减轻内皮损伤,提高临床疗效且安全.

Objective: To explore the effect of nifedipine combined with labetalol for treating pregnant women with hypertension during pregnancy, and to study its influence on the serum adiponectin level and blood viscosity of the women. Methods: A total of 60 pregnant women with hypertension during pregnancy were selected and were randomly divided into two groups(30 cases in each group) from October 2019 to May 2021. The women in the control group were treated with labetalol, and the women in the observation group were treated with nifedipine combined with labetalol. The blood viscosity situation, the blood urea nitrogen level, the 24 h urine protein quantification value, the serum adiponectin level, the high-sensitivity C-reactive protein(hs-CRP) level, the leucine aminopeptidase(LAP) level, the clinical efficacy, and the incidence of adverse reactions of the women were compared between the two groups. Results: The blood viscosity, the levels of serum urea nitrogen, hs-CRP, 24 h urine protein quantitation, and the values of diastolic blood pressure and systolic blood pressure of the women in the two groups after treatment had decreased significantly, and which of the women in the observation group were significantly lower than those of the women in the control group. The levels of serum adiponectin and LAP of the women in the two groups after treatment had increased significantly, and which of the women in the observation group were significantly higher than those of the women in the control group(all P<0.05). The clinical efficacy(90.0%) of the women in the observation group was significantly higher than that(63.3%) of the women in the control group(P<0.05). There was no significant difference in the total incidence(30.0% vs. 13.3%), such as loss of appetite, lower extremity edema, dizziness and fatigue, of the women between the two groups(P>0.05). Conclusion: Nifedipine combined with labetalol in the treatment of hypertension during pregnancy of the women can effectively regulate their blood viscosity,reduce their inflammation response,increase their serum adiponectin and LAP levels,reduce their vascular endothelial damage,and improve their safe and effective of clinical treatment.