多囊卵巢综合征孕妇血清NGAL、AMH、INHB表达特征及与不良妊娠关系

Expression characteristics of serum neutrophil gelatinase-related lipid carrying protein,anti-mullerian tubular hormone,and inhibin B of pregnant women with polycystic ovary syndrome and their correlation with the adverse pregnancy

目的:探讨多囊卵巢综合征孕妇血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、抗苗勒氏管激素(AMH)、抑制素B(INHB)表达水平及与不良妊娠关系.方法:选取2019年8月-2021年8月在本院规律产前检查并分娩的多囊卵巢综合征孕妇93例和健康孕妇50例,分别纳入病例组和对照组,检测两组血清AMH、INHB、NGAL水平,多元线性回归分析其水平与不良妊娠的相关性.结果:病例组不良妊娠发生率(63.4%)高于对照组(22.0%),血清NGAL(100.26±5.26mmol/L)、AMH(9.16±3.02ng/ml)、INHB(146.22±12.23ng/ml)水平均高于对照组(41.22±2.01mmol/L、5.46±0.22ng/ml、100.23±7.06ng/ml),且妊娠结局不良孕妇血清水平均高于结局良好孕妇(均P<0.05).回归分析显示,多囊卵巢综合征孕妇血清NGAL、AMH、INHB水平与不良妊娠均存在相关性(P<0.05).结论:多囊卵巢综合征孕妇血清NGAL、AMH、INHB水平异常升高,其表达水平与不良妊娠发生有关.

Objective: To explore the levels of serum neutrophil gelatinase-related lipid carrying protein(NGAL), anti-mullerian tubular hormone(AMH), and inhibin B(INHB) of pregnant women with polycystic ovary syndrome(PCOS), and to study their correlation with the adverse pregnancy of the women. Methods: 93 pregnant women with PCOS were included in study group and 50 healthy pregnant women were included in control group from August 2019 to August 2021. The levels of serum AMH, INHB, and NGAL of the women in the two groups were detected, and the correlation between which and the adverse pregnancy of the women was analyzed by multiple linear regression. Results: The incidence of adverse pregnancy(63.4%), and the levels of serum NGAL(100.26±5.26 mmol/L), AMH(9.16±3.02 ng/ml), and INHB(146.22±12.23 ng/ml) of the women in the study group were significantly higher than those(22.0%, 41.22±2.01 mmol/L, 5.46±0.22 ng/ml, and 100.23±7.06 ng/ml) of the women in the control group, and which of the women with normal pregnancy outcomes serum level were significantly higher than those of the women with adverse pregnancy outcomes(all P<0.05). Regression analysis showed that the levels of serum NGAL, AMH, and INHB of the pregnant women with PCOS were correlated with their adverse pregnancy(P<0.05). Conclusion: The serum NGAL, AMH, INHB expression of the pregnant women with PCOS increase abnormally, and which are correlated with their adverse pregnancy.