多囊卵巢综合征不孕患者肠道菌群与血清性激素及脂肪因子关系

Correlation between intestinal flora distribution of infertile patients with polycystic ovary syndrome and the levels of their serum sex hormones and adipokines

目的:探讨多囊卵巢综合征(PCOS)不孕患者肠道菌群分布与血清性激素、促甲状腺激素(TSH)及脂肪因子内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、Apelin的关系。方法:回顾性收集2019年1月-2022年1月本院诊治的PCOS不孕患者82例为PCOS组,因输卵管异常所致不孕女性82例为对照组。检测并比较两组肠道菌群含量、促黄体生成素(LH)、睾酮(T)、TSH、促卵泡素(FSH)、雌二醇(E_(2))及Vaspin、Apelin水平,分析PCOS组肠道菌群与血清性激素及Vaspin、Apelin的相关性。结果:PCOS组肠道双歧杆菌(8.64±0.82 lg CFU/g)、乳酸杆菌(9.22±0.84 lg CFU/g)低于对照组(9.92±0.94 lg CFU/g、9.89±0.90 lg CFU/g),肠球菌(8.25±0.79 lg CFU/g)、肠杆菌(9.14±0.87 lg CFU/g)及血清LH、T、E_(2)、FSH、TSH、Vaspin、Apelin水平均高于对照组(7.08±0.67 lg CFU/g、7.21±0.69 lg CFU/g)(均P<0.05);PCOS组双歧杆菌、乳酸杆菌与血清LH、T、TSH、Vaspin、Apelin呈负相关,肠球菌、肠杆菌与LH、T、TSH、Vaspin、Apelin呈正相关(均P<0.05)。结论:PCOS不孕患者肠道菌群失调,且与LH、T、TSH及Vaspin、Apelin均具相关性。

Objective: To investigate the correlation between the distribution of intestinal flora of infertile patients with polycystic ovary syndrome(PCOS) and their levels of serum sex hormones, thyroid-stimulating hormone(TSH), adipokines visceral fat-specific serine protease inhibitor(Vaspin), and Apelin. Methods: 82 infertility patients with PCOS were selected in study group and another 82 women with infertile due to abnormal fallopian tubes were selected in control group from January 2019 to January 2022. The content of intestinal flora, and the levels of luteinizing hormone(LH), testosterone(T), TSH, estradiol(E_(2)), Vaspin, and Apelin of the women were detected and were compared between the two groups. The correlation between the content of intestinal flora of the women in the study group and their levels of serum LH, T, E_(2), FSH, TSH, Vaspin, and Apelin was analyzed. Results: The contents of intestinal bifidobacteria(8.64±0.82 lg CFU/g) and lactobacillus(9.22±0.84 lg CFU/g) of the women in the study group were significantly lower than those(9.92±0.94 lg CFU/g and 9.89±0.90 lg CFU/g) of the women in the control group, but the contents of intestinal enterococcus(8.25±0.79 lg CFU/g) and enterobacter(9.14±0.87 lg CFU/g) of the women in the study group were significantly higher than those(7.08±0.67 lg CFU/g and 7.21±0.69 Lg CFU/g) of the women in the control group. The levels of serum LH, T, E_(2), FSH, TSH, Vaspin, and Apelin of the women in the study group were significantly higher than those of the women in the control group(all P<0.05). The contents of bifidobacterium and lactobacillus of the women in the study group were negatively correlated with their levels of serum LH, T, TSH, Vaspin, and Apelin, while the contents of enterococcus and enterobacter of the women in the study group were positively correlated with their levels of serum LH, T, TSH, Vaspin, and Apelin(all P<0.05).Conclusion:The intestinal flora of the infertility women with PCOS is disorder,and which is significantly correlated with the levels of serum LH,T,TSH,Vaspin,and Apelin of the women.