AMI介入术后近期影响MACE发生的三项指标联合预测分析

Combined prediction analysis of three indexes influencing MACE in the short term after AMI intervention

目的:探讨血清C反应蛋白(C-reactive protein,CRP)、载脂蛋白A-1(Apolipoprotein A-1,ApoA-1)联合B型脑钠肽(B-type brain natriuretic peptide,BNP)对急性心肌梗死(Acute myocardial infarction,AMI)介入术后近期主要不良心血管事件(Major adverse cardiovascular events,MACE)的预测价值。方法:比较AMI术后3个月内发生MACE(37例)与未发生(165例)组CRP、ApoA-1、BNP水平,分析其对MACE的预测价值。结果:发生组CRP、BNP高于未发生组(P<0.05),ApoA-1低于未发生组(P<0.05);三者联合预测AMI术后近期MACE的特异度与曲线下面积高于各指标单独预测(P<0.05)。结论:血清CRP、ApoA-1、BNP联合对AMI术后近期MACE的发生具有良好的预测价值。

Objective:To explore the predictive value of serum levels of C-reactive protein(CRP),apolipoprotein A-1(ApoA-1)and B-type brain natriuretic peptide(BNP)for recent major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI)after interventional surgery.Methods:The levels of CRP,ApoA-1 and BNP were compared between the group with MACE(37 cases)and the group without MACE(165 cases)within 3 months after operation of AMI patients,and the predictive value for MACE was analyzed.Results:CRP and BNP in the occurrence group were higher than those in the non-occurrence group(P<0.05),but ApoA-1 was lower than that in the non-occurrence group(P<0.05).The specificity and area under the curve of the three indexes in combined prediction the recent MACE after operation of AMI patients were higher than those of the each index predicted separately(P<0.05).Conclusion:The combination of serum CRP,ApoA-1 and BNP has good predictive value for the occurrence of recent MACE after operation of AMI patients.