摘要
Angiogenesis is known as a biological pathway that results in the formation of new capillary blood vessels originating from the pre-existing vascular system[1].The mechanism of angiogenesis is complicated because it is associated with multiple intricate interactions between various biological elements including different cells,soluble angiogenic agents,and extracellular molecules.It essentially comprises four discrete sequential stages:(1)Proteolytic enzymes degrade glycoproteins of the basement membrane and other extracellular matrix components which blood vessels are surrounded by them;(2)The activation and migration of endothelial cells;(3)The proliferation of endothelial cells.
