HER2、Cyr61、IGFBP3表达情况对老年子宫内膜癌病人预后的价值

Value of HER2,Cyr61 and IGFBP3 expression in predicting the prognosis in elderly patients with endometrial cancer

目的探讨老年子宫内膜癌病人人表皮生长因子受体-2(human epidermal growth factor receptor 2,HER2)、高半胱氨酸蛋白61(cysteine-rich 61,Cyr61)、胰岛素样生长因子结合蛋白3(insulin-like growth factor binding protein 3,IGFBP3)的表达情况及其对病人预后的价值。方法选择2015年1月至2017年1月我院妇产科收治的124例老年子宫内膜癌病人为子宫内膜癌组,120例老年子宫良性病变病人为良性病变组,另选择同期健康体检老年妇女120例为对照组。采用免疫组化法检测3组子宫内膜组织中HER2、Cyr61、IGFBP3的表达情况,并对子宫内膜癌病人随访5年。结果在对照组、良性病变组和子宫内膜癌组中,HER2的阳性表达率分别为7.5%、18.3%、69.4%,Cyr61的阳性表达率分别为10.0%、12.5%、76.6%,IGFBP3的阳性表达率分别为59.2%、51.7%、29.0%,3组HER2、Cyr61、IGFBP3的阳性表达率差异均有统计学意义(P<0.01)。子宫内膜癌病人的HER2阳性表达与年龄、病理分期、组织分化、淋巴结转移、肌层浸润深度、病理类型相关(P均<0.05),Cyr61阳性表达与病理分期、淋巴结转移、肌层浸润深度、病理类型相关(P均<0.05),IGFBP3阳性表达与淋巴结转移、肌层浸润深度、病理类型相关(P均<0.05)。HER2、Cyr61在子宫内膜癌组织中呈阴性表达者的5年生存率高于阳性表达者,IGFBP3在子宫内膜癌组织中呈阳性表达者的5年生存率高于阴性表达者,差异均有统计学意义(P<0.05)。结论老年子宫内膜癌病人的HER2、Cyr61、IGFBP3存在异常表达,其与肿瘤的淋巴结转移、肌层浸润深度、病理类型和预后密切相关。

Objective To investigate the expression of human epidermal growth factor receptor 2(HER2),cysteine-rich 61(Cyr61)and insulin-like growth factor binding protein 3(IGFBP3)and the value in predicting the prognosis of the elderly patients with endometrial cancer.Methods From January 2015 to January 2017,124 elderly patients with endometrial cancer admitted to Department of Obstetrics and Gynecology of our hospital were selected as endometrial cancer group,120 elderly patients with benign uterine lesions selected as benign lesion group,and 120 elderly women undergoing physical examination in the same period selected as the control group.The expression of HER2,Cyr61 and IGFBP3 among the three groups were detected by immunohistology.The patients with endometrial cancer were followed up for 5 years.Results In the control group,benign lesion group and endometrial cancer group,the positive expression rate of HER2 was 7.5%,18.3%and 69.4%,respectively;The positive expression rate of Cyr61 was 10.0%,12.5%and 76.6%,respectively;The positive expression rate of IGFBP3 was 59.2%,51.7%and 29.0%,respectively,with significant differences among the three groups(P<0.01).The positive expression of HER2 was correlated with age,pathological stage,tissue differentiation,lymph node metastasis,depth of muscle layer invasion and pathological type(all P<0.05).The positive expression of Cyr61 was correlated with pathological stage,lymph node metastasis,depth of muscle layer invasion and pathological type(all P<0.05).The positive expression of IGFBP3 was correlated with lymph node metastasis,depth of muscule layer invasion and pathological type(all P<0.05).The 5-year survival rates of the patients with negative expression of HER2 and Cyr61 were higher than those in the patients with positive expression,and the 5-year survival rate of the patients with positive expression of IGFBP3 was higher than that in the paitents with negative expression.Conclusions The abnormal expression of HER2,Cyr61 and IGFBP3 in the elderly patients with endometrial cancer is closely related to lymph node metastasis,depth of muscle layer invasion,pathological type and the prognosis.