磁休克治疗对重度抑郁症患者脑功能网络的影响

The Effects of Magnetic Seizure Therapy on Brain Functional Network in Major Depressive Disorder

目的 磁休克治疗(MST)是一种新兴的神经调节干预技术,在重度抑郁症(MDD)治疗中得到广泛应用,然而其抗抑郁机制尚不清楚。探索MST对不同疗效MDD患者脑功能网络的调控作用,对MST治疗的抗抑郁作用机制研究具有重要意义。方法 本文对18例MDD患者MST作用前后的静息态脑电进行记录,基于皮尔逊相关方法构建脑功能网络;应用复杂网络理论对比分析脑功能网络拓扑结构的改变;根据HDRS-17评分变化率进一步区分治疗有效组和无效组,对网络特征进行二次比较。结果 MST后,MDD患者的脑功能网络平均节点度、平均聚类系数和平均全局效率值均比治疗前显著升高,平均路径长度值显著降低,小世界属性显著增大;相比于治疗无效组,治疗有效组的脑功能网络特征参数变化量更大。结论 MST显著改变了MDD患者脑功能网络拓扑结构,对患者的脑功能网络具有一定的调制作用,这些结果为MST治疗的抗抑郁机制研究提供了实验支持和理论依据。

Objective Magnetic seizure therapy(MST) is an emerging neuromodulation intervention technique that is widely used in the treatment of major depressive disorder(MDD),but its antidepressant mechanism is still unclear.Therefore,exploring the regulatory effect of MST on the brain functional network of MDD patients with different therapeutic effects is of great significance for the study of the antidepressant mechanism of MST treatment.Methods In this study,the resting-state EEG of 18 MDD patients pre-and post-MST was recorded,and the Pearson correlation method was used to construct the brain functional network;the complex network theory was used to compare and analyze the changes in the topology of the brain functional network;according to the rate of change of the HDRS-17 score,it was further distinguished.The network characteristics were performed a secondary comparison between responders and non-responders.Results The brain functional network connectivity,mean node degree,mean clustering coefficient,and mean global efficiency values were significantly higher than that pre-MST treatment.Mean path length values were significantly lower,and small world attribute significantly increased post-MST treatment.Compared with the group of non-responders,the changes in the characteristic parameters of the brain functional network in the group of responders were significantly larger.Conclusion MST significantly changes the topology of the brain functional network in patients with MDD,and it has a certain modulation effect on the brain functional network of patients.These results provide experimental support and a theoretical basis for the study of the antidepressant mechanism of MST treatment.