子痫前期患者左心房应变功能

Left atrial strain function of patients with preeclampsia

目的探讨利用二维斑点追踪技术评价子痫前期患者左心房功能变化的临床应用价值。方法纳入就诊空军军医大学唐都医院的子痫前期患者33例,另选取年龄及孕周匹配的35例正常妊娠孕妇作为健康对照组。采用Esaote彩色多普勒超声诊断仪Mylab twice测量常规超声指标,将原始数据以Archive原格式导入机器进行左房应变分析。结果子痫前期患者左室舒张末期内径(LVEDD)(P<0.05)、左房容积指数(LAVI)(P<0.01)、舒张早期二尖瓣血流速度(E峰)(P<0.05)、舒张早期二尖瓣环运动速度(e’)及舒张早期二尖瓣血流速度/舒张早期二尖瓣环运动速度比值(E/e’)(P<0.01)较健康对照组显著增大,而左室收缩末期内径、射血分数、E/A比值(舒张早期二尖瓣血流速度/舒张晚期二尖瓣血流速度)无显著差异。子痫前期患者左房应变的储备功能、通道功能、泵功能较健康对照组显著减低,差异具有显著性[储备功能:(54±18)%vs.(76±21)%,(P<0.01);通道功能:(26±19)%vs.(39±19)%,(P<0.05);泵功能:(28±11)%vs.(37±19)%,(P<0.05)]。结论二维斑点追踪技术能够早期评估子痫前期患者左房应变的储备功能、通道功能、泵功能,对左心房功能变化的评价具有重要临床应用价值。

AIM To evaluate the clinical value of left atrial function in patients with preeclampsia by two-dimensional speckle tracking technique.METHODS A total of 33 patients with preeclampsia admitted to Air Force Medical University Tangdu hospital were included in the study group and other 35age and gestational week matched normal pregnant women served as the control group.The conventional ultrasound parameters were measured by Esaote MyLab Twice Color Doppler Ultrasonography.The original data were imported into the machine with original format of Archive and the left atrial strain was analyzed.RESULTS Compared with those in the healthy control group,the left ventricular enddiastolicdiameter and E(P<0.05),left atrial volume index and E/e’were significantly increased in patients with preeclampsia(P<0.01).However,no significant difference was observed in the left ventricular endsystolicdiameter,ejection fraction and E/A between the two groups.Moreover,compared with those in the healthy control group,the left atrial strain reserve function(54±18)%vs.(76±21)%,(P<0.01),conduit function(26±19)%vs.(39±19)%,(P<0.05)and pump function(28±11)%vs.(37±19)%,(P<0.05)were significantly reduced in patients with preeclampsia,indicating a significant difference.CONCLUSION Two-dimensional speckle tracking technology can be used to assess the reserve function,channel function and pump function of left atrial strain in patients with preeclampsia at early stage,which has important clinical application value for the evaluation of left atrial function changes.