慢性失眠障碍患者长期使用苯二氮[艹卓]类药物停药的研究进展

Update on the Withdrawal from Long-term Use of Benzodiazepines in Patients with Chronic Insomnia Disorder

苯二氮[艹卓]类(BZDs)药物适用于慢性失眠障碍的短期治疗,长期大剂量使用可导致严重的不良反应。患者长期应用BZDs可产生耐受性和依赖性,突然停药可出现反跳现象和戒断症状,导致停药困难。因此本文整理分析了目前慢性失眠障碍患者长期使用BZDs停药的相关文献,分别从BZDs概述、停药时机和策略、停药治疗等方面进行综述,旨在为长期使用BZDs的慢性失眠障碍患者如何合理停用BZDs提供借鉴。

Benzodiazepines(BZDs)are indicated for the short-term treatment of chronic insomnia disorder,since real-world use of them in large doses for a long time could cause serious side effects.Patients with long-term use of BZDs are prone to BZDs tolerance and dependence,but sudden withdrawal from BZDs can lead to rebound and withdrawal symptoms,resulting in difficulty in withdrawal.We reviewed recent studies about the withdrawal from long-term use of BZDs in chronic insomnia disorder patients,focusing on the overview of BZDs,timing and strategy of withdrawal,and treatment of withdrawal symptoms.Our review will contribute to enriching the ideas of appropriately discontinuing BZDs in chronic insomnia disorder patients with long-term use of BZDs.