我国生殖及母胎医学研究热点情况——基于国家自然科学基金项目的科学文献分析图谱

Research hotspots of reproductive and maternal-fetal medicine in China based on analysis atlas of scientific literature of National Natural Science Foundation of China

目的探讨当前我国生殖及母胎医学的研究状况和研究热点,为相应学科的发展和研究领域的拓展提供相关的参考依据。方法本研究通过采用COOC文献计量处理软件和VOSviewer软件,分析2015—2019年国家自然科学基金(NSFC)医学科学部H04(生殖医学/围生医学/新生儿)资助项目,比较各年度NSFC的H04资助项目数量和金额、资助机构、资助课题主要疾病分类和研究热点。结果分析发现,NSFC的H04资助项目数量和金额比较稳定,资助的主要机构为国内知名高校;资助课题研究的疾病主要是子痫前期、多囊卵巢综合征(PCOS)、子宫内膜异位症、新生儿(或胎儿)脑损伤、早产、妊娠期糖尿病、复发性流产及勃起障碍;此外,相关的研究热点包括微小RNA(miRNA)、滋养层细胞、长链非编码RNA(lncRNA)、精子、胎盘及基因突变等。结论本研究揭示了2015—2019年间NSFC的医学科学部H04资助项目方面的研究热点情况,希望为相应学科的发展和妇幼健康领域研究思路的拓展提供相关的参考依据。

Objective:To explore the current research status and hotpots in the field of reproductive and maternal-fetal medicine,and provide relevant reference basis for promoting the development of the corresponding subjects and expanding the research scale.Methods:The H04 programs involving reproductive medicine/perinatal medicine/newborn fields supported by the Medical Scientific Department of Natural Science Foundation of China(NSFC)from 2015 to 2019 were analyzed by utilizing the COOC(a software for bibliometrics processing)and VOSviewer software(a software for chart visualization).The number and amount of money of projects and institutions funded by H04 programs of NSFC,main disease classification and research hotspots of NSFC in each year were compared.Results:The analysis found that the number and funds of H04 programs remained stable and the main funding institutions were domestic well-known universities.The studied diseases of the project funded by H04 programs were primarily focused on preeclampsia,polycystic ovary syndrome(PCOS),endometriosis,brain injury of neonates or fetus,preterm birth,gestational diabetes mellitus,recurrent pregnancy abortion and erectile dysfunction.Additionally,the related research hotspots included miRNA,trophoblast cells,long chain noncoding RNA(lncRNA),sperm,placenta and gene mutations etc.Conclusions:This study reveals the research hotspots of the project funded by the H04 programs of Department of Medical Sciences of NSFC from 2015 to 2019,in order to provide relevant reference basis for improving the development of corresponding subjects and stretching the ideas for maternal and child health researches.