糖转运蛋白在多囊卵巢综合征中的研究进展

Research progress of glucose transporters in polycystic ovarian syndrome

多囊卵巢综合征(PCOS)是育龄女性最常见的内分泌紊乱疾病,但其发病机制尚不明确,且缺乏专门的治疗药物。高雄激素血症(HA)和胰岛素抵抗(IR)是诱发PCOS的两大主要病因,且均与糖代谢紊乱有关,目前发现,糖转运蛋白家族(SLC2As)与HA和IR关系密切。本文对SLC2As在PCOS发生发展中的作用展开综述。

Polycystic ovarian syndrome(PCOS)is known as one of the most common endocrine diseases in women of reproductive age.However,its pathogenesis remains unclear,and there is a lack of countermeasures.Currently,it is believed that hyperandrogenemia(HA)and insulin resistance(IR)are the main causes of PCOS,and both of them are closely associated with defected glucose metabolism.Studies have found that the facilitated glucose transporters(SLC2As)are closely related to HA and IR.This paper reviews the current research progress on SLC2As in in the occurrence and development of PCOS.