盐酸川芎嗪注射液联合尤瑞克林对急性脑梗死的疗效及对Ang-Ⅱ、D-二聚体、hs-CRP水平的影响

Effect of Ligustrazine Hydrochloride Injection Combined with Urecolin on Acute Cerebral Infarction and the Ievels of Ang-Ⅱ,D-dimer and hs-CRP

目的研究盐酸川芎嗪注射液联合尤瑞克林对急性脑梗死的疗效及对血管紧张素Ⅱ(Ang-Ⅱ)、D-二聚体、超敏C-反应蛋白(hs-CRP)水平的影响。方法回顾性分析2019年1月~2021年12月石河子市人民医院收治的76例急性脑梗死患者的临床资料,根据治疗方法分为对照组和观察组,各38例。对照组给予尤瑞克林治疗;观察组在尤瑞克林的基础上,联用盐酸川芎嗪注射液治疗。两组患者均治疗14天,观察两组患者的治疗有效率、治疗前后血浆D-二聚体、血管紧张素Ⅱ(Ang-Ⅱ)、血清超敏C-反应蛋白(hs-CRP)水平及脑血流动力学指标(大脑后动脉血流速度、血细胞比容水平、大脑中动脉血流速度、全血低切黏度、大脑前动脉血流速度以及全血高切黏度)。结果观察组急性脑梗死患者的治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的Ang-Ⅱ、D-二聚体和hs-CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的Ang-Ⅱ、D-二聚体和hs-CRP水平均明显降低,差异有统计学意义(P<0.05),且观察组水平明显低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的大脑后动脉血流速度、血细胞比容水平、大脑中动脉血流速度、全血低切黏度、大脑前动脉血流速度以及全血高切黏度比较,差异无统计学意义(P>0.05);治疗后,两组患者的各项指标均明显改善,差异有统计学意义(P<0.05),且观察组指标均明显优于对照组,差异具有统计学意义(P<0.05)。结论盐酸川芎嗪注射液联合尤瑞克林在急性脑梗死治疗中有显著疗效,其机制可能与降低Ang-Ⅱ、D-二聚体、hs-CRP水平有关。

Objective To study the effect of ligustrazine hydrochloride injection combined with urecolin on acute cerebral infarction and the levels of angiotensinⅡ(Ang-Ⅱ),D-dimer and high-sensitivity C-reactive protein(hs-CRP).Methods A retrospective study of 76 patients with acute cerebral infarction admitted to Shihezi People’s Hospitalfrom January 2019 to December 2021 were retrospectively selected and divided into two groups according to the treatment methods,with 38 cases in each group.The control group was given Eurekrine treatment;the observation group was treated with Ligustrazine Hydrochloride Injection on the basis of Eurekrine.The two groups were treated for 14 days,and the eff ective rates of treatment in the two groups were observed,plasma D-dimer,angiotensin II(Ang-II),serum high-sensitivity C-reactive protein(hs-CRP)levels and cerebral blood Fluid dynamics indicators(posterior cerebral artery blood fl ow velocity,hematocrit level,middle cerebral artery blood fl ow velocity,whole blood low shear viscosity,anterior cerebral artery blood fl ow velocity,and whole blood high shear viscosity).Results The eff ective rate of the observation group was signifi cantly higher than control group(P<0.05).Before treatment,there was no signifi cant diff erence in the levels of Ang-Ⅱ,D-dimer and hs-CRP between the two groups(P>0.05).After treatment,the levels of Ang-Ⅱ,D-dimer and hs-CRP in the two groups decreased signifi cantly(P<0.05),and the levels of Ang-Ⅱ,D-dimer and hs CRP in the observation group were signifi cantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in hematocrit,anterior cerebral artery blood flow velocity,whole blood high shear viscosity,middle cerebral artery blood fl ow velocity,whole blood low shear viscosity and posterior cerebral artery blood fl ow velocity between the two groups(P>0.05).After treatment,all indicators in the two groups were signifi cantly improved(P<0.05),andthe indexes in the observation group were signifi cantly better than those in the control group(P<0.05).Conclusion Ligustrazine hydrochloride injection combined with urecolin has a signifi cant eff ect on acute cerebral infarction,and its mechanism may be related to reducing the levels of Ang-Ⅱ,D-dimer and hs-CRP.