静电喷雾法制备聚乳酸/布洛芬微球及其性能研究

Fabrication and properties of poly(lactic acid)/ibuprofen microspheres through electrostatic spray method

采用静电喷雾技术,以聚乳酸(PLA)为骨架载体材料,布洛芬(IBU)为模型药物,成功制备出PLA载IBU微球,利用扫描电子显微镜(SEM)、X射线衍射仪(XRD)、差示扫描量热仪(DSC)、傅里叶变换红外光谱仪(FTIR)、热失重分析仪(TG)和紫外可见分光光度计分析了微球形貌、结构和性能。结果表明,PLA/IBU微球呈表面多孔的无定形结构,分散性较好,IBU以分子或无规则状态负载在PLA中,化学结构未有变化,稳定性较纯IBU有所提高。在体外缓释测试中,PLA/IBU微球相比较纯IBU具有良好的缓释效果,随着投药量的增加,IBU的释放速率和累计释放量逐渐提高,含16%IBU的PLA微球在48 h内累计释放量可达52%。静电喷雾法制备的PLA/IBU微球有望提高IBU的生物利用度和溶出率,在生物医药领域具有潜在的应用前景。

The ibuprofen(IBU)‑loaded poly(lactic acid)(PLA)microspheres were prepared through electrostatic spray using PLA as a skeleton carrier material and IBU as a model drug,and their morphology,microstructure,and properties were investigated using scanning electron microscope,X ray diffractometer,differential scanning calorimeter,infrared spectrophotometer,thermogravimetric analyzer,and UV‑Vis spectrophotometer.The obtained PLA/IBU microspheres showed a porous and amorphous structure with good dispersibility.IBU was loaded in PLA in a molecular or random state and without any changes in chemical structure.Their stability was higher than that of pure IBU.Based on the in vi‑tro controlled release test,The PLA/IBU microspheres exhibited a better effect for controlled release than pure IBU.The release rate and cumulative release amount of IBU from the microspheres increased with an increase in the dosage of IBU.The cumulative release amount of IBU reached 52%at 48 h when the IBU content was 16 wt%.With the bio‑availability and dissolution rate of IBU,the PLA/IBU microspheres developed by this work exhibit great application po‑tential in the biomedicine field.