经鼻持续气道正压通气治疗新生儿肺炎的有效性研究

Study on the effectiveness of nasal continuous positive airway pressure on neonatal pneumonia

目的 对新生儿肺炎采用经鼻持续气道正压通气(CPAP)治疗后的效果进行分析。方法 50例新生儿肺炎患儿,根据等量数字随机方式分为常规组与实验组,各25例。常规组患儿给予鼻导管式吸氧治疗,实验组患儿给予经鼻持续气道正压通气治疗。对比两组患儿治疗效果、不良反应发生率及血气分析指标[pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果 实验组的治疗总有效率为92.00%,高于常规组的68.00%,差异具有统计学意义(P<0.05)。出生时,两组的pH值、PaCO_(2)、PaO_(2)比较,差异无统计学意义(P>0.05);通气2、24 h,实验组的pH值、PaO_(2)高于常规组,PaCO_(2)低于常规组,差异具有统计学意义(P<0.05)。实验组不良反应发生率4.00%(1/25)低于常规组的24.00%(6/25),差异具有统计学意义(P<0.05)。结论 临床中针对新生儿肺炎采用经鼻持续气道正压通气治疗效果显著,可以有效改善患儿的血气分析指标,同时也可以提高患儿的治疗安全性。

Objective To analyze the effect of nasal continuous positive airway pressure(CPAP)on neonatal pneumonia.Methods A total of 50 cases of neonatal pneumonia were randomly divided into conventional group and an experimental group according to equal numbers,with 25 cases in each group.Children in the conventional group were treated with nasal catheter oxygen inhalation,and children in the experimental group were treated with nasal continuous positive airway pressure.The therapeutic effect,incidence of adverse reactions and blood gas analysis indicators[pH value,arterial partial pressure of oxygen(PaO_(2)),and arterial partial pressure of carbon dioxide(PaCO_(2))]were compared between the two groups.Results The total effective rate of the experimental group was 92.00%,which was higher than 68.00% of the conventional group,and the difference was statistically significant(P<0.05).At birth,there was no statistically significant difference in pH,PaCO_(2) and PaO_(2) between the two groups(P>0.05).After 2 and 24 h of ventilation,the pH value and PaO_(2) of the experimental group were higher than those of the conventional group,and the PaCO_(2) was lower than that of the conventional group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 4.00%(1/25),which was lower than 24.00%(6/25)in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Nasal continuous positive airway pressure has significant effect on clinical treatment of neonatal pneumonia,which can not only effectively improve the blood gas analysis indicators of children,but also improve the total effective rate and safety of clinical treatment.