阿替普酶静脉溶栓治疗急性轻型缺血性脑卒中的效果及安全性研究

Effect and safety of intravenous thrombolysis with alteplase in the treatment of acute mild ischemic stroke

目的 分析阿替普酶静脉溶栓治疗急性轻型缺血性脑卒中[美国国立卫生研究院卒中量表(NIHSS)评分≤6分]的效果及安全性。方法 选取64例急性轻型缺血性脑卒中患者作为研究对象,根据NIHSS评分分为观察组(NIHSS评分≤4分, 31例)和对照组(NIHSS评分>4分, 33例)。两组均采用阿替普酶静脉溶栓治疗。比较两组治疗后临床疗效及不良反应发生情况。结果 观察组治疗后总有效率为90.32%,明显高于对照组的69.70%,差异具有统计学意义(P<0.05)。观察组的不良反应发生率为16.13%,低于对照组的30.30%,差异具有统计学意义(P<0.05)。结论 阿替普酶静脉溶栓治疗NIHSS评分≤4分的急性轻型缺血性脑卒中患者的效果显著,能改善患者的神经功能缺损情况,具有较高的安全性。

Objective To analyze the effect and safety of intravenous thrombolysis with alteplase in the treatment of acute mild ischemic stroke[National Institutes of Health stroke scale(NIHSS)score≤6 points].Methods A total of 64 patients with acute mild ischemic stroke were selected as the research subjects and divided into observation group(NIHSS score≤4 points,31 cases)and control group(NIHSS score>4 points,33 cases)according to NIHSS score.Both groups were treated with alteplase intravenous thrombolysis.The clinical efficacy after treatment and occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 90.32%,which was significantly higher than 69.70%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 16.13%,which was lower than 30.30%in the control group,and the difference was statistically significant(P<0.05).Conclusion Alteplase intravenous thrombolysis has significant effect on patients with acute mild ischemic stroke(NIHSS score≤4 points),and can improve the neurological deficit of patients,and has high safety.