氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病的临床疗效分析

Analysis of the clinical efficacy of amlodipine combined with atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease

目的 探讨氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病患者的临床疗效。方法 68例高血压合并冠心病患者,根据治疗方案的不同分为常规组和研究组,每组34例。常规组采取常规治疗方案,研究组采取氨氯地平联合阿托伐他汀钙片治疗。比较两组治疗效果、血脂指标[总胆固醇、低密度脂蛋白胆固醇、甘油三酯及高密度脂蛋白胆固醇]及治疗前后的血压指标[收缩压及舒张压]。结果 研究组治疗总有效率97.06%高于常规组的82.35%,差异有统计学意义(P<0.05)。治疗后,研究组舒张压(65.68±1.22)mm Hg(1 mm Hg=0.133 kPa)及收缩压(135.64±5.02)mm Hg均低于常规组的(88.85±1.88)、(145.84±4.45)mm Hg,差异有统计学意义(P<0.05)。治疗后,研究组总胆固醇(4.62±0.53)mmol/L、低密度脂蛋白胆固醇(3.65±0.32)mmol/L、甘油三酯(1.41±0.48)mmol/L均低于常规组的(5.22±1.51)、(4.72±1.49)、(2.81±1.45)mmol/L,高密度脂蛋白胆固醇(1.55±0.58)mmol/L高于常规组的(1.22±0.35)mmol/L,差异有统计学意义(P<0.05)。结论 将氨氯地平联合阿托伐他汀钙片的治疗方案用于高血压合并冠心病患者的治疗中,效果更加显著,值得推广。

Objective To discuss the clinical efficacy of amlodipine combined with atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease. Methods A total of 68 patients with hypertension and coronary heart disease were divided into conventional group and research group according to different treatment regimens, with 34 cases in each group. The conventional group was treated with conventional therapy, and the research group was treated with amlodipine combined with atorvastatin calcium tablets. Both groups were compared in terms of therapeutic effect, blood lipid indexes [total cholesterol, lowdensity lipoprotein cholesterol, triglyceride and high-density lipoprotein cholesterol] and blood pressure indexes [systolic blood pressure and diastolic blood pressure] before and after treatment. Results The total effective rate of treatment 97.06% of the research group was higher than 82.35% of the conventional group, and the difference was statistically significant(P<0.05). After treatment, the diastolic blood pressure(65.68±1.22) mm Hg(1 mm Hg=0.133 kPa) and systolic blood pressure(135.64±5.02) mm Hg in the research group were lower than(88.85±1.88) and(145.84±4.45) mm Hg in the conventional group, and the differences were statistically significant(P<0.05). After treatment, the total cholesterol(4.62±0.53) mmol/L, low-density lipoprotein cholesterol(3.65±0.32) mmol/L, and triglyceride(1.41±0.48) mmol/L in the research group were lower than(5.22±1.51),(4.72±1.49), and(2.81±1.45) mmol/L in the conventional group, and the high-density lipoprotein cholesterol(1.55±0.58) mmol/L was higher than(1.22±0.35) mmol/L in the conventional group. All the differences were statistically significant(P<0.05). Conclusion Amlodipine combined with atorvastatin calcium has significant effect on patients with hypertension and coronary heart disease, and is worthy of promotion.