左乙拉西坦联合丙戊酸钠对癫痫患者的治疗效果

Effect of levetiracetam combined with sodium valproate on epilepsy patients

目的 探讨左乙拉西坦联合丙戊酸钠对癫痫患者的治疗效果。方法 85例癫痫患者,根据抽签法分为观察组(43例)及对照组(42例)。对照组患者实施常规临床治疗,观察组患者实施左乙拉西坦联合丙戊酸钠治疗。对比两组患者的脑电图改善效果,治疗前后的癫痫发作频率、持续时间及血清指标[超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)]。结果 治疗后,观察组患者的脑电图改善总有效率为86.05%,高于对照组的66.67%,差异具有统计学意义(P<0.05)。治疗后,两组患者的癫痫发作频率低于治疗前、发作持续时间短于治疗前,且观察组患者的癫痫发作频率低于对照组、发作持续时间短于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的hs-CRP、Hcy、TNF-α水平低于本组治疗前,且观察组患者的hs-CRP(4.48±1.52)mg/L、Hcy(11.57±1.34)μmol/L、TNF-α(28.96±2.95)pg/ml低于对照组的(8.69±1.53)mg/L、(17.89±2.93)μmol/L、(55.23±5.67)pg/ml,差异具有统计学意义(P<0.05)。结论 左乙拉西坦联合丙戊酸钠对癫痫患者脑电图指标的恢复效果显著,同时患者的癫痫发作频率降低,持续时间明显缩短,值得临床推广应用。

Objective To discuss the effect of levetiracetam combined with sodium valproate on epilepsy patients.Methods A total of 85 epilepsy patients were divided into observation group(43 cases)and control group(42 cases)according to the lottery method.The control group group received conventional clinical treatment,and the observation received levetiracetam combined with sodium valproate.Both groups were compared in terms of electroencephalogram improvement effect,seizure frequency and duration,and serum indexes[high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),tumor necrosis factor-α(TNF-α)]before and after treatment.Results After treatment,the total effective rate of electroencephalogram improvement in the observation group was 86.05%,which was higher than 66.67%in the control group,and the difference was statistically significant(P<0.05).After treatment,the seizure frequency and duration in the two groups were lower than those before treatment in this group,and the seizure frequency in the observation group was lower than that in the control group,and the seizure duration was shorter than that in the control group.All the differences were statistically significant(P<0.05).After treatment,the levels of hs-CRP,Hcy and TNF-αin the two groups were lower than those before treatment in this group,and the hs-CRP(4.48±1.52)mg/L,Hcy(11.57±1.34)μmol/L,and TNF-α(28.96±2.95)pg/ml in the observation group were lower than(8.69±1.53)mg/L,(17.89±2.93)μmol/L,and(55.23±5.67)pg/ml in the control group.All the differences were statistically significant(P<0.05).Conclusion Levetiracetam combined with sodium valproate has significant effect on electroencephalogram index in patients with epilepsy,and the frequency of epileptic seizures is reduced and the duration is significantly shortened,which is worthy of clinical promotion and application.