拉莫三嗪治疗双相情感障碍抑郁发作的临床疗效

Clinical efficacy of lamotrigine in the treatment of depressive episode of bipolar disorder

目的探索对于双相情感障碍抑郁发作采取拉莫三嗪治疗的临床疗效。方法78例双相情感障碍抑郁发作患者,按照入院治疗时间分为对照组和观察组,每组39例。对照组进行碳酸锂治疗,观察组进行拉莫三嗪治疗。比较两组治疗后不同时期汉密尔顿抑郁量表(HAMD)评分、治疗效果、治疗前后总体印象量表病情严重程度(CGI-SI)评分。结果治疗2周后,两组患者HAMD评分比较,差异无统计学意义(P>0.05)。观察组患者治疗4、6、8周后的HAMD评分分别为(22.19±3.25)、(19.34±2.76)、(14.34±2.17)分,均低于对照组的(26.34±3.88)、(23.58±3.54)、(18.77±2.37)分,差异均具有统计学意义(P<0.05)。观察组治疗总有效率94.87%高于对照组的74.36%,差异具有统计学意义(χ^(2)=6.303,P=0.012<0.05)。治疗后,观察组患者GGI-SI评分(1.57±0.03)分低于对照组的(3.13±0.12)分,差异具有统计学意义(t=78.761,P=0.000<0.05)。结论双相情感障碍抑郁发作采用拉莫三嗪治疗有明显治疗效果,因此值得推广采纳。

Objective To investigate the clinical efficacy of lamotrigine in the treatment of depressive episode of bipolar disorder.Methods A total of 78 patients with depressive episodes of bipolar disorder were divided into control group and observation group according to the time of admission and treatment,with 39 cases in each group.The control group was treated with lithium carbonate,and the observation group was treated with lamotrigine.The Hamilton depression scale(HAMD)score at different time points after treatment,therapeutic effect,and clinical global impression-severity of illness(CGI-SI)score before and after treatment were compared between the two groups after treatment.Results At 2 weeks after treatment,there was no statistically significant difference in HAMD scores between the two groups(P>0.05).The HAMD scores in the observation group at 4,6 and 8 weeks after treatment were(22.19±3.25),(19.34±2.76),and(14.34±2.17)points,which were lower than(26.34±3.88)and(23.58±3.54),and(18.77±2.37)points in the control group,and the differences were statistically significant(P<0.05).The total effective rate 94.87%of the observation group was higher than 74.36% of the control group,and the difference was statistically significant(χ^(2)=6.303,P=0.012<0.05).After treatment,the GGI-SI score(1.57±0.03)points of the observation group was lower than(3.13±0.12)points of the control group,and the difference was statistically significant(t=78.761,P=0.000<0.05).Conclusion Lamotrigine has obvious effect in the treatment of depressive episode of bipolar disorder,so it is worthy of promotion and adoption.