苏子降气汤加减治疗慢阻肺急性加重期患者的临床价值分析

Analysis of the clinical value of modified Suzi Jiangqi Decoction in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

目的 分析苏子降气汤加减治疗慢性阻塞性肺疾病(慢阻肺)急性加重期患者的临床价值。方法 92例慢阻肺急性加重期患者,随机分为对照组与研究组,各46例。对照组采用常规方式治疗,研究组在对照组基础上采用苏子降气汤加减治疗。对比两组治疗前后的炎性因子、血气指标水平,临床疗效、治疗前后各项生命体征。结果 治疗前,两组白细胞计数(WBC)、C反应蛋白(CRP)、动脉血二氧化碳分压(PaCO_(2))、酸碱度(pH)、动脉血氧分压(PaO2)比较,差异无统计学意义(P>0.05);治疗后,研究组WBC(7.78±2.81)×10^(9)/L、CRP(2.21±0.87)mg/L、PaCO_(2)(48.45±3.32)mm Hg(1 mm Hg=0.133 kPa)均低于对照组的(10.30±2.38)×10^(9)/L、(3.64±1.05)mg/L、(54.46±3.64)mm Hg, pH(7.37±0.05)、PaO2(63.24±5.21)mm Hg高于对照组的(7.34±0.04)、(54.21±5.32)mm Hg,差异均有统计学意义(P<0.05)。研究组治疗总有效率为95.65%,高于对照组的82.61%,差异有统计学意义(P<0.05)。治疗前,两组心率、呼吸频率、体温比较,差异无统计学意义(P>0.05);治疗后,研究组心率(86.78±12.81)次/min、呼吸频率(22.21±1.21)次/min、体温(36.45±0.32)℃低于对照组的(94.30±12.38)次/min、(24.54±1.35)次/min、(37.12±1.04)℃,差异有统计学意义(P<0.05)。结论 苏子降气汤加减治疗慢阻肺急性加重期患者,可以达到改善患者的血气指标与炎性因子水平的作用,同时使各项生命体征恢复正常,提高患者的治疗有效率。

Objective To analyze the clinical value of modified Suzi Jiangqi Decoction in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 92 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into control group and research group,with 46 cases in each group.The control group was treated with conventional treatment,and the research group was treated with modified Suzi Jiangqi Decoction on the basis of the control group.Both groups were compared in terms of levels of inflammatory factors and blood gas indexes before and after treatment,clinical efficacy,and various vital signs before and after treatment.Results Before treatment,there was no statistically significant difference in white blood cell count(WBC),C-reactive protein(CRP),arterial partial pressure of carbon dioxide(PaCO_(2)),pH and arterial partial pressure of oxygen(PaO_(2))between the two groups(P>0.05).After treatment,the WBC(7.78±2.81)×10^(9)/L,CRP(2.21±0.87)mg/L,PaCO_(2)(48.45±3.32)mm Hg(1 mm Hg=0.133 kPa)in the research group were all lower than(10.30±2.38)×10^(9)/L,(3.64±1.05)mg/L,(54.46±3.64)mm Hg in the control group,and the pH(7.37±0.05)and PaO_(2)(63.24±5.21)mm Hg were higher than(7.34±0.04)and(54.21±5.32)mm Hg in the control group.All the differences were statistically significant(P<0.05).The total effective rate of the research group was 95.65%,which was higher than 82.61% of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in heart rate,respiratory frequency and body temperature between the two groups(P>0.05).After treatment,the heart rate of the research group was(86.78±12.81)times/min,the respiratory frequency was(22.21±1.21)times/min,and the body temperature was(36.45±0.32)℃,which were lower than(94.30±12.38)times/min,(24.54±1.35)times/min,and(37.12±1.04)℃ of the control group,and the differences were statistically significant(P<0.05).Conclusion Modified Suzi Jiangqi Decoction for patients with acute exacerbation of chronic obstructive pulmonary disease can improve the blood gas index and inflammatory factor level of patients,while normalizing all vital signs and improving the treatment efficiency of patients.