血清ANGPTL4、VE-cadherin水平与急性脑梗死患者颈动脉易损斑块的关系

Relationship between the levels of serum ANGPTL4,VE-cadherin and carotid plaque in patients with acute cerebral infarction

目的 分析血清人血管生成素样蛋白4(ANGPTL4)、血管内皮细胞钙黏连蛋白(VE-cadherin)水平与急性脑梗死患者颈动脉斑块的关系。方法 选取120例急性脑梗死患者作为观察组,另选择120例行体检的健康志愿者作为对照组,比较两组以及不同斑块稳定性患者的ANGPTL4、VE-cadherin水平,分析血清ANGPTL4、VE-cadherin水平与急性脑梗死患者颈动脉易损斑块的关系。结果 观察组的ANGPTL4水平低于对照组,VE-cadherin水平高于对照组(P<0.05);斑块不稳定组的ANGPTL4水平低于斑块稳定组,VE-cadherin水平高于斑块稳定组(P<0.05);斑块不稳定组的内膜厚度、斑块面积高于斑块稳定组(P<0.05);相关性分析发现,ANGPTL4与内膜厚度以及斑块面积呈负相关,VE-cadherin与内膜厚度以及斑块面积呈正相关(P<0.05)。结论 血清ANGPTL4、VE-cadherin水平与急性脑梗死患者颈动脉易损斑块呈显著相关,可作为临床治疗的重要靶点。

Aim To study the relationship between the levels of human angiopoietin like protein 4(ANGPTL4)and vascular endothelial cell cadherin(VE cadherin)in serum and carotid plaque in patients with acute cerebral infarction.Methods 120 patients with acute cerebral infarction were selected as the observation group,and 120 healthy volunteers who underwent physical examination in our hospital were selected as the control group.The ANGPTL4 and VE-cadherin levels in the observation group,the control group and patients with different plaque stability were com-pared,and the relationship between serum ANGPTL4 and VE-cadherin levels and carotid vulnerable plaque in patients with acute cerebral infarction was studied.Results The level of ANGPTL4 in the observation group was lower than that in the control group,and the level of VE-cadherin was higher than that in the control group(P<0.05);The level of AN-GPTL4 in plaque unstable group was lower than that in plaque stable group,and the level of VE-cadherin was higher than that in plaque stable group(P<0.05);The intimal thickness and plaque area of patients in plaque unstable group were higher than those in plaque stable group(P<0.05);Through correlation analysis,ANGPTL4 was negatively correlated with intimal thickness and plaque area,and VE-cadherin was positively correlated with intimal thickness and plaque area(P<0.05).Conclusion The levels of serum ANGPTL4 and VE-cadherin are significantly correlated with vulnerable carotid plaque in patients with acute cerebral infarction,which can be used as important targets for clinical treatment.