桂枝茯苓丸、臭氧注射联合机械疏通治疗输卵管阻塞性不孕症临床观察

Clinical Observation of Guizhi Fuling Pills and Injection of Ozone Combined with Mechanical Dredging in the Treatment of Tubal Obstructive Infertility

目的探讨桂枝茯苓丸、臭氧注射联合机械疏通治疗输卵管阻塞性不孕症的临床疗效及对患者中医证候和再闭塞率的影响。方法选取医院2019年5月至2021年5月收治的输卵管阻塞性不孕症患者104例,按随机数字表法分为观察组和对照组,各52例。两组患者均给予机械疏通治疗,输卵管疏通后注入硫酸庆大霉素注射液和地塞米松磷酸钠注射液;观察组患者联合臭氧注射及桂枝茯苓丸口服。结果治疗后,观察组患者的输卵管疏通率、妊娠率均显著高于对照组,再闭塞率显著低于对照组(P<0.05);月经不调、乳房胀痛、烦躁抑郁、胁肋胀满等中医证候积分均显著低于对照组(P<0.05);血清睾酮、黄体生成素、卵泡刺激素水平均显著优于对照组(P<0.05);C反应蛋白、白细胞介素6、单核细胞趋化因子-1水平均显著低于对照组(P<0.05)。观察组与对照组的不良反应发生率相当(15.38%比11.54%,P>0.05)。结论桂枝茯苓丸、臭氧注射联合机械疏通治疗输卵管阻塞性不孕症,能提高输卵管疏通率和妊娠率,降低再闭塞率,还能改善患者的中医证候和性激素水平,降低机体炎性因子水平。

Objective To investigate the clinical efficacy of Guizhi Fuling Pills and injection of ozone combined with mechanical dredging in the treatment of tubal obstructive infertility and its effect on the traditional Chinese medicine(TCM)syndrome and re-occlusion rate.Methods A total of 104 patients with tubal obstructive infertility admitted to the hospital from May 2019 to May 2021 were selected and divided into the observation group and the control group by the random number table method,with 52 cases in each group.The patients in the two groups were treated with mechanical dredging,and they were injected with Gentamicin Sulfate Injection and Dexamethasone Sodium Phosphate Injection after fallopian tube dredging,on this basis,the patients in the observation group were injected with ozone and given Guizhi Fuling Pills orally.Results After treatment,the fallopian tube dredging rate and pregnancy rate in the observation group were significantly higher than those in the control group,while the re-occlusion rate in the observation group was significantly lower than that in the control group(P<0.05).The TCM syndrome scores of irregular menstruation,breast pain,irritability and depression,and costal fullness in the observation group were significantly lower than those in the control group(P<0.05).The levels of serum testosterone(T),luteinizing hormone(LH)and follicle-stimulating hormone(FSH)in the observation group were significantly better than those in the control group(P<0.05).The levels of C-reactive protein(CRP),interleukin-6(IL-6)and monocyte chemokine protein-1(MCP-1)in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.38%vs.11.54%,P>0.05).Conclusion Guizhi Fuling Pills and injection of ozone combined with mechanical dredging in the treatment of tubal obstructive infertility can increase the tubal dredging rate and pregnancy rate,reduce the re-occlusion rate,improve the TCM syndrome and sex hormone level of patients,and reduce the level of inflammatory factors.