胃息肉患者检测血清胃蛋白酶原、胃泌素-17及幽门螺旋杆菌的临床价值研究

Clinical Value of Detecting Serum Pepsinogen, Gastrin-17 and Helicobacter Pylori of Gastric Polyps Patients

目的探讨胃息肉患者联合检测血清胃蛋白酶原(PG)、胃泌素-17(G-17)及幽门螺旋杆菌(HP)的临床价值。方法选取202例胃息肉患者为观察组,198例体检者为对照组。比较两组PGI、PGII、PGR(PGI/PGII)、G-17水平及不同病理类型息肉HP感染率。结果与对照组相比,观察组血清PGI、PGII显著升高(P<0.05)。其中增生性息肉、炎性息肉及胃底腺息肉PGI高于对照组及腺瘤性息肉。增生性息肉PGII及G-17高于对照组及胃底腺息肉(P<0.05)。胃息肉患者HP感染率为47.52%,其中增生性息肉及炎性息肉HP感染率均高于胃底腺息肉(P<0.05)。结论联合检测血清PG、G-17及HP对诊断不同病理类型、大小及数量的胃息肉具有重要的临床价值。

Objective To investigate clinical value of combined detection of serum pepsinogen(PG),gastrin-17(G-17)and helicobacter pylori(HP)of patients with gastric polyps.Methods The paper chose 202 patients with gastric polyps as observation group and 198 cases physical examiners as control group.Levels of PGI,PGII,PGR(PGI/PGII),G-17 and HP infection rate of polyps of different pathological types were compared between two groups.Results Serum PGI and PGII in observation group were significantly higher than control group,(P<0.05).PGI of proliferative polyps,inflammatory polyps and gastric fundus gland polyps was higher than control group and adenomatous polyps.PGII and G-17 in hyperplastic polyps were higher than control group and gastric fundus gland polyps,(P<0.05).HP infection rate of gastric polyps was 47.52%.HP infection rate of proliferative polyps and inflammatory polyps was higher than gastric fundus gland polyps(P<0.05).Conclusion Combined detection of serum PG,G-17 and HP has important clinical value in diagnosis of gastric polyps with different pathological types,sizes and quantities.