富马酸替诺福韦二吡呋酯对乙型肝炎母婴传播阻断的效果

Effect of Tenofovir Fumarate Dipivoxil on Blocking Mother to Child Transmission of Hepatitis B

目的探究富马酸替诺福韦二吡呋酯在母婴间对乙型肝炎的传播阻断作用与实际应用价值。方法选取研究对象120例(均源自阳江市公共卫生医院就诊患者,选取年限2021年3月-2022年5月),依照治疗方式的差异将患者平均划分为研究组(富马酸替诺福韦二吡呋酯治疗)和对照组(仅进行定时产检和常规保肝治疗,不额外添加抗病毒治疗)进行研究,两组孕妇在分娩后均对新生儿进行常规乙肝疫苗接种及免疫球蛋白治疗。结果两组患者分娩时HBsAg和HBeAg阳性率对比虽无统计学意义,但研究组相较仍更具优势(P>0.05);两组ALT(谷丙转氨酶)水平比较无差异意义(P>0.05),而分娩时研究组log10HBV DNA水平为(3.42±0.75)U/mL低于对照组的(6.38±0.48)U/mL(P<0.05);研究组新生儿出生7个月后的HBsAg和HBeAg阳性率分别为0%、0%均低于对照组的10.00%、11.67%(P<0.05);研究组阻断成功率高于对照组(P<0.05),其不良反应发生率低于对照组,但比较无差异(P>0.05)。结论富马酸替诺福韦二吡呋酯在母婴间对乙型肝炎的传播中具有良好的阻断效果,有效降低了乙肝病毒母婴传播发生率。

Objective To explore blocking effect and practical application value of tenofovir dipivoxil fumarate on transmission of hepatitis B between mother and infant.Methods The paper chose 120 patients(from Yangjiang City Public Health Hospital),selected period:(from March 2021 to May 2022),and divided them into study group(with tenofovir fumarate dipivoxil treatment)and control group(with regular prenatal examination and routine liver protection treatment only,no additional antiviral treatment)according to differences of treatment methods.Both groups received routine hepatitis B vaccination and immunoglobulin therapy for neonatess after delivery.Results Positive rate comparison of HBsAg and HBeAg between two groups was not statistically significant,that of study group had more advantageous than control group,(P>0.05).There was no significant difference in ALT(alanine aminotransferase)between two groups(P>0.05),and log10 HBV DNA level in study group was(3.42±0.75)U/mL,which was lower than control group(6.38±0.48)U/mL(P<0.05);positive rates of HBsAg and HBeAg in study group were 0%and 0%respectively,lower than 10.00%and 11.67%in control group(P<0.05);success rate of blocking in study group was higher than control group(93.33%vs 80.00%)(P<0.05),and incidence of adverse reactions was lower than control group.(5.00%vs 1.67%), there was no significant difference (P>0.05). Conclusion Tenofovir dipivoxil fumarate has goodblocking effect on transmission of hepatitis B virus between mother and infant, can reduce incidence ofmother to infant transmission of hepatitis B virus effectively.